ID H0WQC9_OTOGA Unreviewed; 667 AA.
AC H0WQC9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Outer dynein arm-docking complex subunit 4 {ECO:0000256|ARBA:ARBA00034139};
DE AltName: Full=Tetratricopeptide repeat protein 25 {ECO:0000256|ARBA:ARBA00034143};
GN Name=ODAD4 {ECO:0000313|Ensembl:ENSOGAP00000004150.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004150.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000004150.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03042756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03042757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03042758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03042759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WQC9; -.
DR STRING; 30611.ENSOGAP00000004150; -.
DR Ensembl; ENSOGAT00000004648.2; ENSOGAP00000004150.2; ENSOGAG00000004644.2.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00390000007911; -.
DR HOGENOM; CLU_023648_2_0_1; -.
DR InParanoid; H0WQC9; -.
DR OMA; NKEDLCF; -.
DR TreeFam; TF323661; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0097728; C:9+0 motile cilium; IEA:Ensembl.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0120228; C:outer dynein arm docking complex; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IEA:Ensembl.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0120197; P:mucociliary clearance; IEA:Ensembl.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:Ensembl.
DR GO; GO:0120229; P:protein localization to motile cilium; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR040111; ODAD4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23040:SF1; OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR23040; UNCHARACTERIZED; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 360..393
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 158..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 443..470
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 167..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 76258 MW; EBAE02BD6217919A CRC64;
MVDPEVETLR STFPSYMAEG ERLYLCGEFS KAAQSFSNAL QLQNGDKNCL VARSKCFLKM
GDLEKSLRDA EASLQSDPTF CKGILQKAET LYTMGDFEFA LVFYHRGYKL RPDREFKVGI
QKAQEAINNS VGSPSSIKLE NKGDLSFLSK QAENMRAQQK PHLMKHLSHY SKAESKRRGS
PKSEKTIRQL LGELYVDKEY LEKLLLDEDL IRGTMKSGLT VEDLIMTGIN YLDTRSDFWR
QQKPIYARER DRKLMQEKWL RDRKRSPSQT AHYILKSLED IDMLLTSGSA EGSLQKAEKV
LKKVLEWNKE EVPNKDELVG NLYSCIGNAQ IELGQMAAAL QSHRKDLEIA KEYDLPDAKS
RALDNIGRVY ARVGKFQQAV DMWEEKIPLA KTTLEKTWLF HEIGRCYLEL DQAWQAQAYG
EKSQQCAEEE GDIEWQLNAS VLVAQAQVKL RDFESAVNNF EKALERAKLV HNNEAQQAIL
SALDDANKGI IEELKKTNYR EHFKEKKDKE EATSLFEDKT LTAKKEKSGE IDEPEKVMKE
WEREQIESDK ETEDDEGFRE GPESTAGRQH RVGAEKARRD PGKGAKEHDT KSGRTALGRR
LSRDIYRRPS GESSQRLIGE LSRKESEGLE KKLSEVGRRK LGEQGETELG EKGEIKKTEN
GEKTEKD
//
