GenomeNet

Database: UniProt
Entry: H0WRG0_OTOGA
LinkDB: H0WRG0_OTOGA
Original site: H0WRG0_OTOGA 
ID   H0WRG0_OTOGA            Unreviewed;      1863 AA.
AC   H0WRG0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   07-JUN-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A {ECO:0000313|Ensembl:ENSOGAP00000004614};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004614, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000004614}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000004614}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000004614}.
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DR   EMBL; AAQR03076460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03076469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000004614; -.
DR   Ensembl; ENSOGAT00000005159; ENSOGAP00000004614; ENSOGAG00000005154.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0WRG0; -.
DR   OMA; YMIDEDH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    129    152       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    200    220       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    232    249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    255    275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    399    423       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    766       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    828    856       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    915    941       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1149   1168       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1180   1199       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1219   1242       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1263   1291       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1388   1414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1473   1491       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1503   1521       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1533   1553       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1590   1618       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1693   1716       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      132    430       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      451    666       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    945       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      955   1142       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1147   1422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1472   1726       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      420    458       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1863 AA;  212283 MW;  204AF2DD8A7E01D1 CRC64;
     MAARLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED SKPKPNSDLE
     AGKSLPFIYG DIPQGLVAVP LEDLDPYYLT QKRTFVVLNR GKTLFRFSAT PALYILSPFN
     LIRRIAIKIL IHSLFSMIIM CTILTNCVFM TFSNPPDWSK NVEYTFTGIY TFESLVKIIA
     RGFCIDGFTF LRDPWNWLDF SVIMMAYVTE FVDLGNVSAL RTFRVLRALK TISVIPGLKT
     IVGALIQSVK KLSDVMILTV FCLSVFALIG LQLFMGNLRN KCVVWPINFN ESYLENGTKG
     FDWEEYINNK TNFYTVAGML EPLLCGNSSD AGQCPEGYQC MKAGRNPNYG YTSFDTFSWA
     FLALFRLMTQ DYWENLYQLH CMMPITLRIR NMSPSYMNFF VLVIFVGSFY LVNLILAVVA
     MAYEEQNQAT LEEAEQKEAE FKAMLEQLKK QQEEAQSSSE LSKLSSKSAK ERRNRRKKRK
     QKELSEGEEK GDPEKFDPYW KEKQQHCFSI PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE
     NEFADDEHST VEESEGRRDS LFIPIRARER RSSYSGYSGY SQGSRSSRIF PSLRRSVKRN
     STVDCNGVVS LIGGPGSHIG GRLLPEVKID KAATDDSQNS FNSVSGVSMD QLASYGRKDR
     INSIMSVVTN TLVEELEESQ RKCPPCWYKF ANTFLIWECH PYWIKLKEIV NLIVMDPFVD
     LAITICIVLN TLFMAMEHHP MTPQFEHVLT VGNLVFTGIF TAEMFLKLIA MDPYYYFQEG
     WNIFDGFIVS LSLMELGLAD VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG
     NLTLVLAIIV FIFAVVGMQL FGKSYKECVC KINQDCELPR WHMHDFFHSF LIVFRVLCGE
     WIETMWDCME VAGQAMCLIV FMMVMVIGNL VVLNLFLALL LSSFSADNLA ATDDDGEMNN
     LQISVIRIKK GVAWIKVKVH AFMQAHFKQR EADEVKPLGK EGQLYCQPHW CNGNGTTSGI
     GSSVEKYIID EDHMSFINNP NLTVRVPIAV GESDFENLNT EDVSSESDPE GSKDKLDDTS
     SSEGSTIDIK PEVEEVPVEQ PEEYLDPDAC FTEGCVQRFK CCQVNIEEGL GKSWWILRKT
     CFLIVEHNWF ETFIIFMILL SSGALVRSRV ECDKGLAGNI FMEYSEAAVI IVYVIIMVLK
     DGCFSFKYHF PNPWVWLNLY SVDVSLVSLI ANALGYSELG AIKSLRTLRA LRPLRALSRF
     EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKYHYCFNET SEIRFEIEVV
     NNKTECEKLM EGNNTEIRWK NVKINFDNVG AGYLALLQVA TFKGWMDIMY AAVDSRKPDE
     QPKYEDNIYM YIYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN
     AMKKLGSKKP QKPIPRPVNK IQGIVFDFVT QQAFDIVIMM LICLNMVTMM VETDTQSKQM
     ENILNWINLV FVIFFTCECV LKMFALRHYY FTIGWNIFDF VVVILSIVGM FLADIIEKYF
     VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIFSIFGM
     SNFAYVKHEA GIDDMFNFET FGNSMICLFQ ITTSAGWDGL LLPILNRPPD CSLDKEHPGS
     GFKGDCGNPS VGIFFFVSYI IISFLIVVNM YIAIILENFS VATEESADPL SEDDFETFYE
     IWEKFDPDAT QFIEYCKLAD FADALEHPLR VPKPNTIELI AMDLPMVSGD RIHCLDILFA
     FTKRVLGDSG ELDILRQQME ERFVASNPSK VSYEPITTTL RRKQEEVSAV VLQRAYRGHL
     ARR
//
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