ID H0WRV1_OTOGA Unreviewed; 331 AA.
AC H0WRV1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=WD repeat and FYVE domain containing 2 {ECO:0000313|Ensembl:ENSOGAP00000004778.2};
GN Name=WDFY2 {ECO:0000313|Ensembl:ENSOGAP00000004778.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004778.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000004778.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR EMBL; AAQR03175050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03175051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03175052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WRV1; -.
DR STRING; 30611.ENSOGAP00000004778; -.
DR Ensembl; ENSOGAT00000005342.2; ENSOGAP00000004778.2; ENSOGAG00000005337.2.
DR eggNOG; KOG1409; Eukaryota.
DR GeneTree; ENSGT00940000158527; -.
DR HOGENOM; CLU_046919_0_0_1; -.
DR InParanoid; H0WRV1; -.
DR OMA; DYNQITH; -.
DR TreeFam; TF314470; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR CDD; cd15718; FYVE_WDFY1_like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR042234; WDFY1/WDFY2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46189; LD41958P; 1.
DR PANTHER; PTHR46189:SF3; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT REPEAT 126..159
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 169..210
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 212..283
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REPEAT 293..326
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 331 AA; 36972 MW; DECA0BD8D30EDC9C CRC64;
LTFSPSSRSM SEGGGLCPGG GVGAFWQAWD WHKKLTPSPN ENAHQSRVTM ILFVLELEWV
LSTGQDKQFA WHCSESGQRL GGYRTSAVAS GLQFDVETRH VFIGDHSGQV TILKLEQENC
TLVTTFRGHS GGVTALCWDP VQRVLFSGSS DHSVIMWDIG GRKGTAIELQ GHNDRVQALS
YAQHTRQLIS CGGDGGIVVW NMDVERQETP EWLDSDSCQK CDQPFFWNFK QMWDSKKIGL
RQHHCRKCGK AVCGKCSSKR SSIPLMGFEF EVRVCDSCHE AITDEERAPT ATFHDSKHNI
VHVHFDATRG WLLTSGTDKV IKLWDMTPVV S
//
