ID H0WVE2_OTOGA Unreviewed; 897 AA.
AC H0WVE2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
GN Name=POLK {ECO:0000313|Ensembl:ENSOGAP00000006275.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006275.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006275.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03040020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WVE2; -.
DR STRING; 30611.ENSOGAP00000006275; -.
DR Ensembl; ENSOGAT00000007011.2; ENSOGAP00000006275.2; ENSOGAG00000007007.2.
DR eggNOG; KOG2094; Eukaryota.
DR GeneTree; ENSGT00940000156667; -.
DR HOGENOM; CLU_012348_11_3_1; -.
DR InParanoid; H0WVE2; -.
DR OMA; SWHNFLD; -.
DR TreeFam; TF314387; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0090734; C:site of DNA damage; IEA:Ensembl.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:Ensembl.
DR GO; GO:0006297; P:nucleotide-excision repair, DNA gap filling; IEA:Ensembl.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 2.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SMART; SM00734; ZnF_Rad18; 2.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
DR PROSITE; PS51908; ZF_UBZ4; 2.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01256}.
FT DOMAIN 103..386
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT DOMAIN 647..677
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT DOMAIN 803..833
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 873..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 102137 MW; C004789C044CC62A CRC64;
MDSTKEKYDN HKDDLLLRMG LNDNKAGMEG LDKEKINKII MEATKGSRFY VNELKKEKQV
NQRIENMIQQ KAKITSQQLW KAQVQVDRFA MELEQSRNLN NTIVHIDMDA FYAAVEMRDN
PELQDKPIAV GSVSMLSTSN YHARRFGVRA AMPGFIAKRL CPQLIIVPPN FDKYRAVSKE
VKEILADYDP NFMATSLDEA YLNITKHLQE RQNWPDDKRR YFIRNSVEND KPGNKVNKLN
EHERSISPLL FEDSLPDLQP SGNPFQVNSE EQNNPQILEN SVVFGTSAEE VVKEIRFRIE
QKTKLTASAA MNLEYLIISF SLGKFRPVQD SIAAPRDMDG IAPNTMLAKI CSDKHKPNGQ
YQILPNREAV MDFIKDLPIR KVSGVGKVTE KMLKALGIIT CTELYQQRAL LSLLFPETSW
HYFLHISLGL GSTYLARDGE RKSMSVERTF SEINKAEEQY SLCQELCSEL AQDLQKEGLK
GRTVTIKLKN VNFEVKTRAS TVSSVVSTAE EIFAIAKELL RTEIDADFPH PLRLRLMGVR
ISSFPNEEDK KQQQKSIIGF LQAGNQSLSA TNCILKKTDK DQFVKPLEIS QKESFFDKKR
LERKLSHQDA FKETMNKQSL QKSQPFQVLK KMNENLETSE NSDNCQIFTC PVCFREQRLI
SLEDFNKHVD ACLDGPSISE SAKTSSCSHA SSTEVNKEEN VHYSFSLCEK QNYEAHLKNR
EITLANCVDL EGALDSSSKA ECVDTLNNRL SKEEYSSLPR KSFNIENGLQ NFCTVSLENE
DLTLLSRQES HQPYSYEVIT GQTLICPVCN LEQKTSDLTL FNEHVDICLN KGIIQELRKD
KVNPVNQCKE SSRSTGGSSR VQKTVTVTKR PGLMTKHSAS KKIKPNNSKH TLDTFFK
//
