ID H0WVI6_OTOGA Unreviewed; 874 AA.
AC H0WVI6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=PML nuclear body scaffold {ECO:0000313|Ensembl:ENSOGAP00000006327.2};
GN Name=PML {ECO:0000313|Ensembl:ENSOGAP00000006327.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006327.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006327.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AAQR03026381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WVI6; -.
DR STRING; 30611.ENSOGAP00000006327; -.
DR Ensembl; ENSOGAT00000007070.2; ENSOGAP00000006327.2; ENSOGAG00000007066.2.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00510000048454; -.
DR HOGENOM; CLU_009136_1_0_1; -.
DR InParanoid; H0WVI6; -.
DR OMA; KPICCIC; -.
DR TreeFam; TF336434; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:GOC.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR GO; GO:0032183; F:SUMO binding; IEA:Ensembl.
DR GO; GO:0140037; F:sumo-dependent protein binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
DR GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
DR GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
DR GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Ensembl.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0010761; P:fibroblast migration; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Ensembl.
DR GO; GO:0051457; P:maintenance of protein location in nucleus; IEA:Ensembl.
DR GO; GO:0030099; P:myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0090402; P:oncogene-induced cell senescence; IEA:Ensembl.
DR GO; GO:0030578; P:PML body organization; IEA:Ensembl.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:2000758; P:positive regulation of peptidyl-lysine acetylation; IEA:Ensembl.
DR GO; GO:1901798; P:positive regulation of signal transduction by p53 class mediator; IEA:Ensembl.
DR GO; GO:0032206; P:positive regulation of telomere maintenance; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0031503; P:protein-containing complex localization; IEA:Ensembl.
DR GO; GO:0010522; P:regulation of calcium ion transport into cytosol; IEA:Ensembl.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:2000779; P:regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:0044790; P:suppression of viral release by host; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd19804; Bbox1_TRIM19_C-V; 1.
DR CDD; cd19770; Bbox2_TRIM19_C-V; 1.
DR CDD; cd16579; RING-HC_PML_C-V; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR021978; PML-like_CC.
DR InterPro; IPR047153; TRIM45/56/19.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR PANTHER; PTHR25462:SF301; PROTEIN PML; 1.
DR Pfam; PF12126; DUF3583; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 54..89
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 121..163
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 181..219
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 292..319
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 486..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 98721 MW; B7425BE4AE07FB11 CRC64;
EEPAPSGSSR PQRKLAFQRT PTMPPPDNPS EDQLPNPSHT EEATKDDEFQ FLHCQHCRME
AKCPKLLPCL HTLCSGCLEP PVTQCPICQE PWPPGTDTPV LDNVFFESLQ RRLSVYRQIV
DARAVCVRCK EVADFWCFEC EQLLCAQCFE AHQWFLKHEA RPLAELRSKS VHEFLDGTRK
SNNIFCSNSN HRSPELTSIY CRGCSKPLCC TCALLDSSHS DLKCDINLEI EQRQKELDSM
TQGLQEQDSA FGEVHAQMSA VVSQLGHRRS EMEALIRERV REVVKHVEAQ ERNLLEAVKE
RYERDYEEMA RQLGSLNTKL QRIRMGGMLV QKMRRFASDQ EVMDMHGFLR EALRRLCQEQ
PQTPQATVHT DSFDEFRARL EVLTSSITQG TDAVLCNRAS PLRDASDDDL PEEVPQRVQM
QAQAEATALE LAENQCMAVV QSVPGAHPKP MYAYSIKDSS YREEIPKIAV PQKRKSCQTE
CPRKVIKMES EEDKEAKLAL NSSEQPRPST SRAVSPPHLD GLPSPKTPIK EADISSLNSS
HGTDDIEEAE NCVFVISSSE DSDAEHSSSR EQDDSSSESS DFQLDSPSSL GVLDESLTDL
QAEDRPLVFF DLKIDNETQK ISQLAAVNQE SKFRVVIEPK AAYTIYSKAV SLEVGLKHFI
NFLSSMRCPI LVSYKLWGPD LLNFFWALED INKLWEFQEA ISGFLAARPL IRKCVPGASS
FKLKNLAKTY LARNMSKHSA MATVLAMRDL CHLLDVSPGP QLAQHVYPFG TLQCFVSLHP
LVQATMLTWA EARLLALNSV SFLELLRAYR RDRQAGLKKY SCYLSLQSMV SHPDQPAFRL
QALSSYFEGL ALAWEEDVYS LIGHSLAGRT FQWS
//
