ID H0WVL5_OTOGA Unreviewed; 321 AA.
AC H0WVL5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Solute carrier family 25 member 33 {ECO:0000313|Ensembl:ENSOGAP00000006361.2};
GN Name=SLC25A33 {ECO:0000313|Ensembl:ENSOGAP00000006361.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006361.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006361.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CTP(out) + UTP(in) = CTP(in) + UTP(out); Xref=Rhea:RHEA:73531,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:46398;
CC Evidence={ECO:0000256|ARBA:ARBA00036351};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; AAQR03101396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03101397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003793300.1; XM_003793252.2.
DR AlphaFoldDB; H0WVL5; -.
DR STRING; 30611.ENSOGAP00000006361; -.
DR Ensembl; ENSOGAT00000007104.2; ENSOGAP00000006361.2; ENSOGAG00000007103.2.
DR GeneID; 100952741; -.
DR KEGG; oga:100952741; -.
DR CTD; 84275; -.
DR eggNOG; KOG0757; Eukaryota.
DR GeneTree; ENSGT00940000158954; -.
DR HOGENOM; CLU_015166_6_0_1; -.
DR InParanoid; H0WVL5; -.
DR OMA; AFYNGMG; -.
DR OrthoDB; 4772at2759; -.
DR TreeFam; TF314220; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:1990314; P:cellular response to insulin-like growth factor stimulus; IEA:Ensembl.
DR GO; GO:0031930; P:mitochondria-nucleus signaling pathway; IEA:Ensembl.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:Ensembl.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IEA:Ensembl.
DR GO; GO:0006390; P:mitochondrial transcription; IEA:Ensembl.
DR GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:1990519; P:pyrimidine nucleotide import into mitochondrion; IEA:Ensembl.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
DR GO; GO:0002082; P:regulation of oxidative phosphorylation; IEA:Ensembl.
DR GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR049562; SLC25A33/36-like.
DR PANTHER; PTHR45829; MITOCHONDRIAL CARRIER PROTEIN RIM2; 1.
DR PANTHER; PTHR45829:SF5; SOLUTE CARRIER FAMILY 25 MEMBER 33; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 9..118
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 126..213
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 231..315
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 321 AA; 35576 MW; 5AE39992DEBA9B19 CRC64;
MATGTQQKEN TLLHLFAGGC GGTVGAIFTC PLEVIKTRLQ SSRLALRTVY YPQVHLGTIS
GAGMVRPTSV TPGLFQVLKS ILEKEGPKSL FRGLGPNLVG VAPSRAVYFA CYSKAKEQFN
GIFVPNSNIV HIFSAGSAAF ITNSLMNPIW MVKTRMQLER KVRGSKQMNT LQCARYVYQT
EGIRGFYRGL TASYAGISET IICFAIYESL KKYLQEEPLA SSTNGTEKNS TNFFGLMAAA
AISKGCASCI AYPHEVIRTR LREEGTKYKS FIQTARLVFR EEGYLAFYRG LFAQLIRQIP
NTAIVLSTYE LIVYLLEDRT Q
//
