ID   H0WW64_OTOGA            Unreviewed;       392 AA.
AC   H0WW64;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=sarcosine oxidasee (formaldehyde-forming) {ECO:0000256|ARBA:ARBA00012769};
DE            EC=1.5.3.1 {ECO:0000256|ARBA:ARBA00012769};
GN   Name=PIPOX {ECO:0000313|Ensembl:ENSOGAP00000006604.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006604.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000006604.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O2 + sarcosine = formaldehyde + glycine + H2O2;
CC         Xref=Rhea:RHEA:13313, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:57305,
CC         ChEBI:CHEBI:57433; EC=1.5.3.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000323};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the MSOX/MTOX family.
CC       {ECO:0000256|ARBA:ARBA00010989}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAQR03132720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03132721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03132722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03132723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0WW64; -.
DR   STRING; 30611.ENSOGAP00000006604; -.
DR   Ensembl; ENSOGAT00000007385.2; ENSOGAP00000006604.2; ENSOGAG00000007383.2.
DR   eggNOG; KOG2820; Eukaryota.
DR   GeneTree; ENSGT00390000011000; -.
DR   HOGENOM; CLU_007884_2_2_1; -.
DR   InParanoid; H0WW64; -.
DR   OMA; WPMLWAH; -.
DR   TreeFam; TF313837; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005777; C:peroxisome; IEA:Ensembl.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0050031; F:L-pipecolate oxidase activity; IEA:Ensembl.
DR   GO; GO:0008115; F:sarcosine oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0033514; P:L-lysine catabolic process to acetyl-CoA via L-pipecolate; IEA:Ensembl.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR045170; MTOX.
DR   InterPro; IPR006281; SoxA_mon.
DR   NCBIfam; TIGR01377; soxA_mon; 1.
DR   PANTHER; PTHR10961; PEROXISOMAL SARCOSINE OXIDASE; 1.
DR   PANTHER; PTHR10961:SF7; PEROXISOMAL SARCOSINE OXIDASE; 1.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          9..366
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
SQ   SEQUENCE   392 AA;  44050 MW;  D7CCCF0E6FC5DDB2 CRC64;
     MAAQKDFWDA IVLGAGIQGC FTAYHLAKHR KQVLLLEQFF LPHSRGSSHG QSRIIRKAYA
     DDFYTQMMDE CYRIWAQLEQ ESGTQLYRKT GLLLVGPKEN PELKTIQATL SRQRIEHQCL
     SSEELKQHFP NIRLPQGEVG LLEKSGGVLY ADRALRTLQD AVRQLGGTVR DGEKVMEIKP
     GLPVVVKTSC GSYQAKSLII TAGPWTNCLL RPLGIELPLQ TLRINVCYWR EKSPGSYGVV
     PAFPCFLGLG QAPHHIYGLP EGEYPGLVKV CYHHGNHTDP DERDCPTARP DIQDVQILCR
     FVKDHLPGLK PEPAIMERCM YTNTPDEHFI LDRHPKYDNI VIGAGFSALG HGFKLAPVVG
     KILYELSMKL TPSYDLTPFR ISRFHGLGKA HL
//