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Database: UniProt
Entry: H0WW84_OTOGA
LinkDB: H0WW84_OTOGA
Original site: H0WW84_OTOGA 
ID   H0WW84_OTOGA            Unreviewed;      1088 AA.
AC   H0WW84;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   SubName: Full=SLIT-ROBO Rho GTPase activating protein 1 {ECO:0000313|Ensembl:ENSOGAP00000006628.2};
GN   Name=SRGAP1 {ECO:0000313|Ensembl:ENSOGAP00000006628.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006628.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000006628.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AAQR03146499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03146508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0WW84; -.
DR   STRING; 30611.ENSOGAP00000006628; -.
DR   Ensembl; ENSOGAT00000007413.2; ENSOGAP00000006628.2; ENSOGAG00000007402.2.
DR   eggNOG; KOG3565; Eukaryota.
DR   GeneTree; ENSGT00950000182824; -.
DR   HOGENOM; CLU_005715_0_0_1; -.
DR   InParanoid; H0WW84; -.
DR   OMA; LIVESCV; -.
DR   TreeFam; TF315892; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04383; RhoGAP_srGAP; 1.
DR   CDD; cd11955; SH3_srGAP1-3; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035648; srGAP1/2/3_SH3.
DR   PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR14166:SF15; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          21..314
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          506..694
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          743..802
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          475..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..957
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1004..1040
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1053..1088
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          352..379
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        808..830
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        831..860
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1024..1040
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1059..1077
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1088 AA;  124102 MW;  64155B52B5FD9226 CRC64;
     MCSGLEFRRN DTHFFAIQTQ KEIRAQLVEQ QKCLEQQTEM RVQLLQDLQD FFRKKAEIET
     EYSRNLEKLA ERFMAKTRST KDHQQYKKDQ NLLSPVNCWY LLLNQVRRES KDHATLGDIY
     LNNVITRFTQ ISEDSTRMFK KSKEIAFQLH EDLMKVLNEL YTVMKTYHMY HAESISAESK
     LKEAEKQEEK QMGRSGDPVL HMRLEERHQR RSSVKKIEKM KEKRQAKYSE NKLKSIKARN
     EYLLTLEATN ASVFKYYIHD LSDLIDCLGQ EFHVSNSRSC CLYLLSAEYN LETSRHEGLD
     IIENAVDNLE PRSDKQRFME MCPAAFCPPV KFEFQSHMGD EVCQVSAQQP VQAELTLRYQ
     QLQSRLATLR IENEEVKKTT EATLQTIQDM VTIEDYDVSE CFQHSRSTES VKSTVSETYL
     SKPSIAKRRA NQQETEQFYF TDLSEYLSGT KDLTCLKCPD FLLQKRIPAG HRAEYMTTRP
     PNVPPKPQKH RKSRPRSQYN AKLFNGDLET FVKDSGQAIP LIVESCIRFI NLYGLQHQGI
     FRVSGSQVEV NDIKNSFERG ENPLADDQSN HDINSVAGVL KLYFRGLENP LFPKERFNDL
     ISCIRVDNLY ERALHIRKLL LTLPRSILTV MRYLFAFLNH LSQYSDENMM DPYNLAICFG
     PTLMPVPETQ DQVSCQAHVN EIVKTIIIHH ETIFPDAKEL DGPVYEKCMA GDDYCDSPYS
     EHGTLEEVDQ DAGTEPHTSE DECEPIEAIA KFDYVGRSAR ELSFKKGASL LLFHRASEDW
     WEGRHNGIDG LVPHQYIVVQ DMDDTFSDTL SQKADSETSS GPVTEDRSSS KDMNSPTDRH
     SDGYLARMSR QRKRGEPPPP VRRPGRTSDG HCPLHPPHAL SNSSVDLGSP SLASHPRGLL
     QNRGLNSDSP ERRRRPGHGS LTNISRHDSL KKMDSPPIRR STSSGQYTGF GDHRPLDPET
     IAQDIEETMN TALSELRELE RQSTAKHAPD VVLDTLEQVK NAPAPATTSE ALSPLHNVAL
     RGSEPQIRRS TSSSSDAMST FKPMVAPRMG VQLKPPALRP KPAVLPKTNP TMGPAPPSQG
     PTDKSCTM
//
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