ID H0WW84_OTOGA Unreviewed; 1088 AA.
AC H0WW84;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=SLIT-ROBO Rho GTPase activating protein 1 {ECO:0000313|Ensembl:ENSOGAP00000006628.2};
GN Name=SRGAP1 {ECO:0000313|Ensembl:ENSOGAP00000006628.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006628.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006628.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAQR03146499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03146508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WW84; -.
DR STRING; 30611.ENSOGAP00000006628; -.
DR Ensembl; ENSOGAT00000007413.2; ENSOGAP00000006628.2; ENSOGAG00000007402.2.
DR eggNOG; KOG3565; Eukaryota.
DR GeneTree; ENSGT00950000182824; -.
DR HOGENOM; CLU_005715_0_0_1; -.
DR InParanoid; H0WW84; -.
DR OMA; LIVESCV; -.
DR TreeFam; TF315892; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF15; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 21..314
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 506..694
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 743..802
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 475..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 352..379
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 808..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1077
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1088 AA; 124102 MW; 64155B52B5FD9226 CRC64;
MCSGLEFRRN DTHFFAIQTQ KEIRAQLVEQ QKCLEQQTEM RVQLLQDLQD FFRKKAEIET
EYSRNLEKLA ERFMAKTRST KDHQQYKKDQ NLLSPVNCWY LLLNQVRRES KDHATLGDIY
LNNVITRFTQ ISEDSTRMFK KSKEIAFQLH EDLMKVLNEL YTVMKTYHMY HAESISAESK
LKEAEKQEEK QMGRSGDPVL HMRLEERHQR RSSVKKIEKM KEKRQAKYSE NKLKSIKARN
EYLLTLEATN ASVFKYYIHD LSDLIDCLGQ EFHVSNSRSC CLYLLSAEYN LETSRHEGLD
IIENAVDNLE PRSDKQRFME MCPAAFCPPV KFEFQSHMGD EVCQVSAQQP VQAELTLRYQ
QLQSRLATLR IENEEVKKTT EATLQTIQDM VTIEDYDVSE CFQHSRSTES VKSTVSETYL
SKPSIAKRRA NQQETEQFYF TDLSEYLSGT KDLTCLKCPD FLLQKRIPAG HRAEYMTTRP
PNVPPKPQKH RKSRPRSQYN AKLFNGDLET FVKDSGQAIP LIVESCIRFI NLYGLQHQGI
FRVSGSQVEV NDIKNSFERG ENPLADDQSN HDINSVAGVL KLYFRGLENP LFPKERFNDL
ISCIRVDNLY ERALHIRKLL LTLPRSILTV MRYLFAFLNH LSQYSDENMM DPYNLAICFG
PTLMPVPETQ DQVSCQAHVN EIVKTIIIHH ETIFPDAKEL DGPVYEKCMA GDDYCDSPYS
EHGTLEEVDQ DAGTEPHTSE DECEPIEAIA KFDYVGRSAR ELSFKKGASL LLFHRASEDW
WEGRHNGIDG LVPHQYIVVQ DMDDTFSDTL SQKADSETSS GPVTEDRSSS KDMNSPTDRH
SDGYLARMSR QRKRGEPPPP VRRPGRTSDG HCPLHPPHAL SNSSVDLGSP SLASHPRGLL
QNRGLNSDSP ERRRRPGHGS LTNISRHDSL KKMDSPPIRR STSSGQYTGF GDHRPLDPET
IAQDIEETMN TALSELRELE RQSTAKHAPD VVLDTLEQVK NAPAPATTSE ALSPLHNVAL
RGSEPQIRRS TSSSSDAMST FKPMVAPRMG VQLKPPALRP KPAVLPKTNP TMGPAPPSQG
PTDKSCTM
//