ID H0WWB9_OTOGA Unreviewed; 2460 AA.
AC H0WWB9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00013058};
DE EC=6.4.1.2 {ECO:0000256|ARBA:ARBA00013058};
GN Name=ACACB {ECO:0000313|Ensembl:ENSOGAP00000006667.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006667.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006667.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-
CC CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001448};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11309;
CC Evidence={ECO:0000256|ARBA:ARBA00001448};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR EMBL; AAQR03070116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000006667; -.
DR Ensembl; ENSOGAT00000007455.2; ENSOGAP00000006667.2; ENSOGAG00000007444.2.
DR eggNOG; KOG0368; Eukaryota.
DR GeneTree; ENSGT00940000155049; -.
DR HOGENOM; CLU_000395_5_0_1; -.
DR InParanoid; H0WWB9; -.
DR OMA; TEHCKVA; -.
DR TreeFam; TF300061; -.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:Ensembl.
DR GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0031999; P:negative regulation of fatty acid beta-oxidation; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0060421; P:positive regulation of heart growth; IEA:Ensembl.
DR GO; GO:0010884; P:positive regulation of lipid storage; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR GO; GO:0031667; P:response to nutrient levels; IEA:Ensembl.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF1; ACETYL-COA CARBOXYLASE 2; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 259..761
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 414..609
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 888..962
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1695..2025
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 2029..2347
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT REGION 29..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2460 AA; 276936 MW; 18BC288188B0035A CRC64;
MVLLLFVSCL IFSCLTFSWL RIWRKMTDSQ PVTKSKSEVS STQSQEPFPA SDSFGEPPQK
NGDGSSLPKT PQQAEPVSRR GPKDACQRRN SLPPSHQKPP RNPLSSTDAS PSPGLQSNGA
ESEGPEAPDT NGLSSLPQPQ GQRARSPSKE DKKQANIKKQ LMTNFILGSF DDYSSDEDPG
TGSFRESSRK GSRASLGTVT LEVPLTTGEP DTRIPTMRPS MSGLHLVKRG REHKKLDLHR
DFTVASPAEF VTRFGGDRVI EKVLIANNGI AAVKCMRSIR RWAYEMFRNE RAIRFVVMVT
PEDLKANAEY IKMADQYVPV PGGPNNNNYA NVELIVDIAK RIPVQAVWAG WGHASENPKL
PELLCKDGIA FLGPPSEAMW ALGDKIASTI VAQTLQIPTL PWSGSGLTVE WTDDDLQQGK
RISVPEDVYE KGCVKDVDEG LEAAEKIGFP LMIKASEGGG GKGIRKAESA EDFPILFRQV
QSEIPGSPVF LMKLAQHARH LEVQILADQY GNAVSLFGRD CSIQRRHQKI IEEAPATIAP
LAVFEFMEQC AVRLAKTVGY VSAGTVEYLY SQDGSFHFLE LNPRLQVEHP CTEMIADVNL
PAAQLQIAMG VPLHRLKDIR LLYGESPWGV MPISFETPAN PPLARGHVIA ARITSENPDE
GFKPSSGTVQ ELNFRSSKNV WGYFSVAATG GLHEFADSQF GHCFSWGENR EEAISNMVVA
LKELSIRGDF RTTVEYLINL LETDSFQNND IDTGWLDHLI AEKVQAEKPD IMLGVVCGAL
NVADAMFRTC MTDFLHSLER GQVLPADSLL NIVDVELIYG GIKYILKVAR QSLTMFVLIM
NGCHIEIDAH RLNDGGLLLS YNGNSYTTYM KEEVDSYRIT IGNKTCVFEK ENDPTVLRSP
SAGKLTQYTV EDGGHVEAGS SYAEMEVMKM IMTLNVQESG RVKYIKRPGA VLEAGCMVAR
LELDDPSKVH PAEPFMGELP SQQTLPILGE KLHQVFHNVL ENLTNVMSGY CLPEPIFSIK
LKEWVQKLMV TLRHPSLPLL ELQEIMTSVS GRIPTPVEKA VQRVMAQYAS NITSVLCQFP
SQQIATILDC HAATLQRKAD REVFFMNTQS IVQLVQRYRS GTRGYMKTVV LDLLRRYLHV
EHHFQQAHYD KCVINLREKF KPDMSQVLDC IFSHAQVAKK NQLVIMLIDE LCGPDPSLSD
ELTSILNELT QLSKSEHCKV ALRARQVLIA SHLPSYELRH NQVESIFLSA IDMYGHQFCP
ENLKKLILSE TTIFDVLPSF FYHTNKVVCM ASLEVYVRRG YIAYELNSLQ HRQLPDGTCV
VEFQFMLPSS HPNRMAMPIS ITNPDLLRHS TELFMDSGFS PLCQRMGAMV AFERFEDFTR
NFDEVISCFA NVPKDTPLFS KARTSLYSDD DCKSLREEPI HILNVAIQCA DRLEDEALVQ
TLRTFVQSKK NILVDYGLRR ITFLIAQEKE FPKFFTFRAR DEFAEDRIYR HLEPALAFQL
ELSRMRNFDL TAVPCANHKM HLYLGAAKVK EGAEVTDHRF FIRAIIRHSD LITKEASFEY
LQNEGERLLL EAMDELEVAF NNTSVRTDCN HIFLNFVPTV IMDPSKIEES VRSMVMRYGS
RLWKLRVLQA EVKINIRQTT TGSAVPIRLF ITNESGYYLD ISLYKELTDP RSGNIMFHSF
GNKQGPQHGM LINTPYVTKD LLQAKRFQAQ SLGTTYIYDF PEMFRQALFK LWGSPDKYPK
DILTYTELVL DSQGQLVEMN RLPGGNEVGM VAFKMRFKTQ EYPEGRDVIV IGNDITFRIG
SFGPREDLLY LRASEMARAE GIPKIYLAAN SGARIGMAEE IKHMFQVAWV DPEDPQKGFK
YLYLTPQDFT KISSLNSVHC KHIEEGGESR YVITDIIGKD DGLGVENLKG SGTIAGESSL
AYEEIVTISL VTCRALGIGA YLVRLGQRVI QVENSHIILT GASALNKVLG REVYTSNNQL
GGVQIMHYNG VSHITVPDDF EGVYTILEWL SYMPKDNLSP VPIITPTDPI DREIEFLPSR
APYDPRWMLA GRPHPTLKGT WQSGFFDHGS FKEIMAPWAQ TVVTGRARLP LGGIPIGVIA
VETRTVELVV PADPANLDSE AKIIQQAGQV WFPDSAYKTA QAIEDFRREK LPLLIFANWR
GFSGGMKDMY DQVLKFGAYI VDGLRKYTQP ILIYIPPYAE LRGGSWVVVD ATINPLCIEM
YADKESRGGV LEPEGTVEIK FRKKDLIKSM RRLDPVYKKL VEQLGAPELS EKERKDLDSR
LKAREDMLFP IYHQVAVQFA DLHDTPGRML EKGVISDILE WKTARTFLYW RLRRLLLEDQ
VRQEILRASG QLSHVHIQSM LRRWFVESEG AVKAYLWDNN QVVVQWLEQH WQAEDGPHST
ISENIRCLKH DSVLKTIRGL VQENPEVAMD CVMYLSQHIS PAERAQVAHL LSTLESPAST
//
