ID H0WWI6_OTOGA Unreviewed; 444 AA.
AC H0WWI6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Polypeptide N-acetylgalactosaminyltransferase like 5 {ECO:0000313|Ensembl:ENSOGAP00000006746.2};
GN Name=GALNTL5 {ECO:0000313|Ensembl:ENSOGAP00000006746.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006746.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006746.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680}.
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DR EMBL; AAQR03087193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03087194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03087195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03087196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WWI6; -.
DR STRING; 30611.ENSOGAP00000006746; -.
DR Ensembl; ENSOGAT00000007543.2; ENSOGAP00000006746.2; ENSOGAG00000007538.2.
DR eggNOG; KOG3736; Eukaryota.
DR GeneTree; ENSGT00940000162156; -.
DR HOGENOM; CLU_013477_0_0_1; -.
DR InParanoid; H0WWI6; -.
DR OMA; FNWHLQF; -.
DR TreeFam; TF313267; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR11675:SF17; INACTIVE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE-LIKE PROTEIN 5; 1.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 138..320
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF00535"
SQ SEQUENCE 444 AA; 51505 MW; C427D70402C7193F CRC64;
RRNVIIRCLL YGSLTFGMWT TLFFLYLHRI HTHYLEKTSQ ELSSAWYLEQ SEQQPITQDP
QPPSKAHVVV KNKPEKLQTF TVLGENINYS DPKLLDGLSK YGFNTITSTN VGFKREVPDT
RHKMCLQNHY STHLPTASVI ICFHNEEFNA LFRTMFSVVN LTPNSLLEEI ILVDDMSEFD
DLKEKLDYVL EVFRGKIKLI RNQKREGLIR GRMIGAARAS GDVLVFLDSH CEVNKGWLEP
LLYSIAKDHK MVVCPLIDVI DETTLEYRAS PVVRGAFDWE LKFKWDNVFS YEMDGPDRPI
KPIRSPAMAG GIFAIYRHYF NEIGQYDKGM DLWGGENLEL SLRIWMCGGQ LFIIPCSRVG
HITKKQFKEV SAITRAFTRN SLRMVHVWLD EYKEQFFLRK PGLRSIAYGN ISERVELRKR
LGCKSFQWYL DTVFPELEAS VNSS
//
