ID H0WX58_OTOGA Unreviewed; 411 AA.
AC H0WX58;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Abhydrolase domain containing 3, phospholipase {ECO:0000313|Ensembl:ENSOGAP00000007015.2};
GN Name=ABHD3 {ECO:0000313|Ensembl:ENSOGAP00000007015.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007015.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007015.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4
CC family. {ECO:0000256|ARBA:ARBA00010884}.
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DR EMBL; AAQR03029507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03029516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012657549.1; XM_012802095.1.
DR AlphaFoldDB; H0WX58; -.
DR STRING; 30611.ENSOGAP00000007015; -.
DR Ensembl; ENSOGAT00000007838.2; ENSOGAP00000007015.2; ENSOGAG00000007835.2.
DR GeneID; 100964527; -.
DR KEGG; oga:100964527; -.
DR CTD; 171586; -.
DR eggNOG; KOG1838; Eukaryota.
DR GeneTree; ENSGT00950000182902; -.
DR HOGENOM; CLU_032487_4_0_1; -.
DR InParanoid; H0WX58; -.
DR OMA; LDWHGPH; -.
DR OrthoDB; 3665677at2759; -.
DR TreeFam; TF313195; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008970; F:phospholipase A1 activity; IEA:Ensembl.
DR GO; GO:0004623; F:phospholipase A2 activity; IEA:Ensembl.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000952; AB_hydrolase_4_CS.
DR InterPro; IPR012020; ABHD4.
DR PANTHER; PTHR10794; ABHYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10794:SF50; PHOSPHOLIPASE ABHD3; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF005211; Ab_hydro_YheT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS01133; UPF0017; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 140..381
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 411 AA; 46234 MW; BABB68E297CAA380 CRC64;
MQSLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYACYYLS SIAKKPQLVT
GAESFSRFLR DHCPVVTETY YPTVWCWESR GQTLLRPFIT SKPLVQYRNE LIKTADGGQI
SLDWFDNDNS PCYMDASARP TILLLPGLTG TSKESYILHM IHLSEELGYR CVVFNNRGVA
GENLLTPRTY CCANTEDLET VVHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGPKTPLM
AAATFSVGWN TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQI DMDHVMKAKS
IREFDKRFTS VMFGYPTIDD YYTDASPNRR LKSVAIPVLC LNSVDDVFSP SHAIPVETAK
QNPNVALVLT SHGGHIGFLE GIWPRQSTYM DRVFKQFVQA MVEHGHELSN M
//
