ID H0WXG3_OTOGA Unreviewed; 1241 AA.
AC H0WXG3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007143.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007143.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; AAQR03081312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03081320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WXG3; -.
DR STRING; 30611.ENSOGAP00000007143; -.
DR Ensembl; ENSOGAT00000007981.2; ENSOGAP00000007143.2; ENSOGAG00000007970.2.
DR eggNOG; KOG3599; Eukaryota.
DR GeneTree; ENSGT00940000161577; -.
DR HOGENOM; CLU_000913_1_0_1; -.
DR InParanoid; H0WXG3; -.
DR OMA; LYIRTSI; -.
DR TreeFam; TF316484; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR PANTHER; PTHR10877:SF134; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 2; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 243..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 996..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1036..1053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1085..1105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1125..1147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1187..1212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 287..404
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 1241 AA; 139753 MW; 3B87D8F75B8947DF CRC64;
LLHNNPCSWF QMMSFPKSPF QAQSHFDVSG TVGGLCLTSP SGRLIPVMNL SENIEILLPR
PPERHSDPTV LNLTSPEALQ VNVTSREAAL GIQLHWRPSI RLTLSLGFGY HPNETSYDAQ
THLLPAAAPA DEMSTWILSP RDLHFGEGVY YLTVVPEADM EPASGRDLTV GITTFLSHCV
FWDEVQEMWD NSGCQVGPRT SPSQTHCLCN HLTFFGSTFL VMPNAVDVRQ TAELFATFED
NPVVVATVGC LCVVYVLAVI WARRKDAQDQ AKVKVTVLED NDPFAQYHYL VTVYTGHRRG
AATSSKVTLT LYGLDGESEP HHLSDPDTPV FERGGVDAFL LSTLFPLGEL QSLRLWHDNS
GDRPSWYVSR VLVCDLAMDQ KWYFLCNSWL SIDVGDCVLD KVFPVATEQD RKQFSHLFFM
KTSTGFQDGH IWYSIFSRSA WSNFTRVQRV SCCFSLLLCT MLTSIMFWSI PQDPAEQKMD
LGKIEFTWQE VMIGLESSLL MFPINLLIVQ IFRNTRPRAV KELDTKKISL CLSLLSSLPS
MLLLTVNDYL EHLALNNSNE VYVLCLCQHD PWCMWPASYL LRQCLYLQLK HLEQALQLVG
PHGFPQQHSH TRALQQLQTL KGCLGGQPGS LAPAYTSPDP LPQAEMIQNS SEYSGRPGTY
SPLKSTSQFM TIVIRMSRPP GGLPWWCIFV GWLLVAATSV VAAFFTMLYG LHYGRASSLR
WLLSMAVSFM ESMFITQPLK VLGFAAFFAL VLKRVDEEED MTAPLAGHLS HPDSLVPLGR
RNSSRDVYQP PLTTTIEKMR AAHLKEQKAF ALIREILDPS FFLTLKILQQ PLLAIRTKFK
CPTVASATLS ALSGPRKPLD VAAEWGVHIW LDGLQNRAKG KKKVVNDTHV GLGLFLTAKP
VLPTNTEARD RPGMVYFRIR AGRCGRNTLP FPWGILCLRR TIVTILVKLA SKHPYPQIIT
KQKSKNKKNK KKTLKCTFFT HAALQSLRLY PFTDGWHPFV VAAELVYFLF LLYYMVVQGK
LMRRQKWGYF RSKWNLLELT IILASWSALA MFVKRAILAE RDIQHCRTHR KEGVSFGETA
AADAAVGYIM AFLVLLSTVK LWHLLRLNPK MNMITSALRR AWGDISGFVI VILIMLLAYS
IASNLIFGWK LRSYKTLFDA AETMISLQLG VFNYEEVLAY SPVLGSFLIG SCIVFMTFVV
LNLFISVILV AFSEEQKCPQ LSEEGEIADL LLMKILSLLG I
//
