ID H0WYC5_OTOGA Unreviewed; 1189 AA.
AC H0WYC5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Synapse defective Rho GTPase homolog 2 {ECO:0000313|Ensembl:ENSOGAP00000007502.2};
GN Name=SYDE2 {ECO:0000313|Ensembl:ENSOGAP00000007502.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007502.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007502.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03023180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03023181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03023182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03023183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03023184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03023185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03023186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WYC5; -.
DR STRING; 30611.ENSOGAP00000007502; -.
DR Ensembl; ENSOGAT00000008378.2; ENSOGAP00000007502.2; ENSOGAG00000008376.2.
DR eggNOG; KOG1452; Eukaryota.
DR GeneTree; ENSGT01030000234635; -.
DR HOGENOM; CLU_005764_1_0_1; -.
DR InParanoid; H0WYC5; -.
DR OMA; PMLKSPF; -.
DR TreeFam; TF323458; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF1; RHO GTPASE-ACTIVATING PROTEIN SYDE2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 658..777
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 814..1026
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1189 AA; 132089 MW; 5C61BCDFE21D9A2B CRC64;
MHDLPPDSSV RRGGGGLAEH GCPAGVWASG QPSHPGGAAD RQACPGDWEW GGGDRPRRQV
SPPRSPRRES EAGRLGTSRM RLQCSRSLDS LRVDAKPPPF QRWPSDSWIR CGARQDWDEP
PPRGGGMDRW RGGSARAVAP AGLLPPGSKG RGRSSGSPFG DPAGSSVLRC GKGDRQEGPL
KPPAVTVKKL QKWMYKGRLL SLGMKGSGRG TSPKVTGAQA SSPHLGALKV HENRVLSVPP
DQRITFTDLF ENVYESSMKR RELKDLKDNI EFSGQKPLNS ITVSKKRNWL YQSTLRSLNL
EGENKKCQDR SQLSISPVSL PKHQLSQPFF SSSEEYCTYM MCNATNSSLS RNCSLDFNEE
NDADDEGEIW YNPIPEDDDL GIASALRFGE ADSAVLKLPV DSLSTLSGSD LTKAEQHAED
LLCSSEHGSD IQAMPSSEVN PVDSIHAEFV QQYKQRLGRK TQECMMVEDS PVLKSPFAGP
GILAATNRTE LGVTEPSSPT PSPVKKGNSI NWSLPDKIKS PRTVRKLSMK MKKLPEFSRK
LSAKGTLNYI NSPDNTLSLS KCNCPEIHHT VILPSGNTAT AAKRNVISRY HLDTSVSSQH
SYQKKTSVSS KYSCKGGYLS DGDSPELITK SSKHGSENKF GKGKEIISNS CSKNEIDIDA
FRHYSFSDQP KCSQYISGLM SVHFYGAEDL KPPRIDSKDV FCAIQVDSVN KARTALLTCR
TTFLDMDHTF NIEIENAQHL KLVVFSWEPT PRKNRVCCHG TVVLPTLFRV TKTHQLAVKL
EPRGLIYVKV TLMEQWENSL NGLDINCEPV MFGVDIRKVV EKENVGLTVP LLIQKCITEI
EKRGCQVLFH YRLSGKDTGQ QRLRKGMTQL DKPVGCPFQS PTASDLFTKG VLKDYLRELP
SPLITKQLYE AVLDAMAKSP LKMSSSGCEN DPSDSKFAVD LLDCLPEIEK TTNTFLGVDI
CGAYKLGSAF TNLAVCFGPV LLSQRQETST HNNRVFTDSE ELASALDFKK HIEVLHYLLQ
LWPVQRLTGK ESTDNLFPEQ KSSLNYLRRK KERPYMLDLS GSDSSGVLRP RQTRLDSPLS
NRYAGDWSSC GENYFLSTRE NLNDVDYDDV PSEDRENGEN YSKVSGPEIM IKQPLPMSRE
CTFQTYLTMQ TIESTMDRKV NLKDLQESID TLIGNLEREL NKNKLNMSI
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