ID H0WYF3_OTOGA Unreviewed; 1538 AA.
AC H0WYF3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=ASXL transcriptional regulator 1 {ECO:0000313|Ensembl:ENSOGAP00000007537.2};
GN Name=ASXL1 {ECO:0000313|Ensembl:ENSOGAP00000007537.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007537.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007537.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Asx family. {ECO:0000256|ARBA:ARBA00006391}.
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DR EMBL; AAQR03054074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03054083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000007537; -.
DR Ensembl; ENSOGAT00000008418.2; ENSOGAP00000007537.2; ENSOGAG00000008413.2.
DR eggNOG; ENOG502QWT2; Eukaryota.
DR GeneTree; ENSGT00520000055578; -.
DR HOGENOM; CLU_247862_0_0_1; -.
DR InParanoid; H0WYF3; -.
DR OMA; VEVEMCF; -.
DR TreeFam; TF328464; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0035517; C:PR-DUB complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042974; F:nuclear retinoic acid receptor binding; IEA:Ensembl.
DR GO; GO:0042975; F:peroxisome proliferator activated receptor binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0048539; P:bone marrow development; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0003007; P:heart morphogenesis; IEA:Ensembl.
DR GO; GO:0030097; P:hemopoiesis; IEA:Ensembl.
DR GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
DR GO; GO:0060430; P:lung saccule development; IEA:Ensembl.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0035359; P:negative regulation of peroxisome proliferator activated receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0072015; P:podocyte development; IEA:Ensembl.
DR GO; GO:0048386; P:positive regulation of retinoic acid receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0035564; P:regulation of kidney size; IEA:Ensembl.
DR GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR InterPro; IPR026905; ASX-like_PHD.
DR InterPro; IPR024811; ASX/ASX-like.
DR InterPro; IPR028020; ASX_DEUBAD_dom.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR044867; DEUBAD_dom.
DR PANTHER; PTHR13578; ADDITIONAL SEX COMBS LIKE PROTEIN ASXL; 1.
DR PANTHER; PTHR13578:SF19; POLYCOMB GROUP PROTEIN ASXL1; 1.
DR Pfam; PF13919; ASXH; 1.
DR Pfam; PF05066; HARE-HTH; 1.
DR Pfam; PF13922; PHD_3; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 11..85
FT /note="HTH HARE-type"
FT /evidence="ECO:0000259|PROSITE:PS51913"
FT DOMAIN 254..363
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 92..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1538 AA; 165259 MW; 929838D1CFEA7EC8 CRC64;
MKDKQKRKKE RTWAEAARLV LENYSDAPMT PKQILQVIEA EGLKEMSGTS PLACLNAMLH
SNSRGGEGLF YKLPGRISLF TLKKDALQWS RNPAAAEGEE PEDTADVESC GSNEASTVSG
ENDVSLDETS SNASCSTESH SRPLSNPRDS YRASSQANKQ KKKTGVMLPR VVLTPLKVNG
AHVESASGFS GRHADGESGS PSSSSSGSLA LGSTAIRGQA EVAQDPAPLL RGFRKPATGQ
MKRNRGEEID FETPGSILVN TNLRALINSR TFHALPSHFQ QQLLFLLPEV DRQVGTDGLL
RLSSSALNNE FFTHAAQSWR ERLADGEFTH EMQVRIRQEM EKEKKVEQWK EKFFEDYYGQ
KLGLTKEESL KQNVGQEEAE IKSGLRIPGE SVRPQRSVAT RQRDGHFKKR SRPDLRTRAR
RNLYKKQEPE QAGVAKDAKS VAPDIPLYKD GEAETNLAGR SSPHLPGMSS AAPNPEGPKF
PAEPTGSQIP TELDNLARAS ASPDRIPNLP PETVDQEPKD QKRKSFEQTA SASFPEKKPR
LEDRQSFRNT IESVHTEKPQ PTKEEPKVPP IRIQLSRIKP PWVVKGQPTY QICPRIIPIT
EPSYRGWTGA RTLADIKARA LQVRGARGHQ CHREAATTAI GGGGGPGGGG GGATDEGGGR
SSSSSGDGSE ACGHPEPRGT PSTPGECASD LQRTQLLPPC SLSGEHTQAG TAVSKARRED
LASPEQEESC PLQRVPGVFT RGLEDASQLP IAPTGDQPCQ ALPPLSSQTP VTERLVEQPK
LHLDVRTECE SGTTFWEGDY EEQGPRVLPE EGPVQSLVGD VLEEGTALAL DSDPTVTGPV
DVTLSSIPES SLGDCLQDKP FDDKVGLGDP CPYMRESDPR REHLKTKVLI SDSATPWLPI
PSDDEVVKQP DLESRENVPR IEPQIGEEWE KTPFIPALPG GLTAKESLDP SGSLPSHWTV
LSKGGVDSIG SAYKQVDAEK LKINGDSEAV SPHSESTETA SDFEGHLTED SSDGDTTEAT
VVKGSSVDKD EKHDWNRFAS LSKVNGDLNL VTRTDGMVAS QSWVSRVCAV PQKIPDSLLL
ASTEYQLKPT CPARPGPLVE PTNSLVIQFL QSKLPLENVL PPAHAGSKPE SPQLSLTKEQ
SHSGMGGLHH PGENGHGVIR SSPTSLSTLK EPLLPKSYDV GTNLARIGTT QAAGVPQKIS
KTAPSFDSLH TVTHPMTSSG KIEGLGSKEQ FSSFNFEDQK EIHAMSQCSN SNAAPGKSPG
DLTTSRAPCF SSPNVISFGS EQTGRALADQ DNVVGQGKKL FGSGSVAATL QRPRPADPTP
LPAEVPPVFP IGKLGPSKNS VSGGIQTATE DWAPKPPPAS LGSIKNEKTF VGDPVKTSAE
SKKAVGHSPL DLVGHLQGMP FVMDLPFWKL PQEPGKGLSE PLEPSSIPSQ LNIKQAFYGK
LSKLQLSSTS FNYSSSSPSF PKGLAGSVVQ LSHKANFGAS HSASLSLQMF TDSSTVESIS
LQCACSLKAM IMCQGCGAFC HDDCIGPSKL CVLCLVVR
//