ID H0X3E4_OTOGA Unreviewed; 1130 AA.
AC H0X3E4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Integrin subunit alpha 6 {ECO:0000313|Ensembl:ENSOGAP00000009638.2};
GN Name=ITGA6 {ECO:0000313|Ensembl:ENSOGAP00000009638.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009638.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000009638.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AAQR03167010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03167011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03167012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03167013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03167014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003800924.1; XM_003800876.2.
DR AlphaFoldDB; H0X3E4; -.
DR STRING; 30611.ENSOGAP00000009638; -.
DR Ensembl; ENSOGAT00000010773.2; ENSOGAP00000009638.2; ENSOGAG00000010765.2.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000155353; -.
DR HOGENOM; CLU_004111_1_0_1; -.
DR InParanoid; H0X3E4; -.
DR OMA; HYINRTV; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:Ensembl.
DR GO; GO:0038132; F:neuregulin binding; IEA:Ensembl.
DR GO; GO:0031589; P:cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0010668; P:ectodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0035878; P:nail development; IEA:Ensembl.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043589; P:skin morphogenesis; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 24..1130
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001424854"
FT TRANSMEM 1052..1076
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 30..95
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 101..166
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 283..339
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 340..402
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 403..456
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 457..518
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 503..663
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 665..830
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 836..1042
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1130 AA; 126376 MW; F344CB5895A2B694 CRC64;
MAAAGQLCLL YLSAGLLPRL GAAFNLDTHE DNVIRKSGDP GSLFGFSLAM HWQLQPEDKR
LLLVGAPRAE ALPLQKANRT GGLYSCDITS RGPCTRVEFD NDADPTSESK EDQWMGVTVQ
SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR
GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG
GETEHDESLV PVPANSYLGL LFLTSISYTD PDQFVYKTRP PREQPDTAPD VMMNSYLGFS
LDSGKGIVSK DDITFVSGAP RANHSGAVVL LKRDLKSAHL LPEHIFDGEG LASSFGYDVA
VVDLNKDGWQ DIIIGAPQYF DRGGEVGGAV YVYMNQQGRW NNVKPIRLNG TKDSMFGIAV
KNIGDINQDG YPDIAVGAPY DDMGKVFIYH GSANGINTKP TQVLEGTSPY FGYSIAGNMD
LDRNSYPDVA VGSLSDSVTV FRARPVINIQ KTITVTPKRI DLRQKTVCGA PSGICLKVKA
CFEYTAKPAG YNPSISIVGT LEAEKERRKS GLSSRVHFRN QGSEPRYIQE LTLNRQKQKM
CMEETLWLQE NIRDKLRPIP ITASVEIKEP SSRRRVNSLP EVLPILNSNE PKTVQTDVHF
LKEGCGDDNV CNSNLKLEYK FCTREGSQDK FSYLPIQKGV PELVLKDQKD IALEITVTNS
PSNPRNPKKD GDDAHEAKLI ATFPDTLTYS AYRELRAFPE KQLSCVANQN GSQADCELGN
PFKRNSSVTF YLILSTTEVT FDTTDLDINL KLETTSNQDN LASITAKAKV VIELLLSVSG
VAKPSQVYFG GTVVGEQAMR SEDEVGSLIE YEFRVINLGK PLKNLGTATL NIQWPKEISN
GKWLLYLVKV ESKGLEKITC EPQNEINLLK LKESHNSRKK REIAEKQIDD NRKFSLFAER
KYQTLNCSMN VNCVNIRCPL RGLDSKASLV LRSRLWNSTF LEEYSKLNYL DILVRASIDV
SAAAENIKLP NAGTQVRVTV FPSKTAAQYS GVPWWIILVA VLAGILMLAL LVFLLWKCGF
FKRSRYDDSV PRYHAVRIRK EEREIKDEKY NDNLEKKQWI TKWNENESYS
//
