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Database: UniProt
Entry: H0X418_OTOGA
LinkDB: H0X418_OTOGA
Original site: H0X418_OTOGA 
ID   H0X418_OTOGA            Unreviewed;       885 AA.
AC   H0X418;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   20-DEC-2017, entry version 28.
DE   SubName: Full=N-deacetylase and N-sulfotransferase 1 {ECO:0000313|Ensembl:ENSOGAP00000009913};
GN   Name=NDST1 {ECO:0000313|Ensembl:ENSOGAP00000009913};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009913, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000009913}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000009913}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000009913}.
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DR   EMBL; AAQR03008282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03008283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03008284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03008285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03008286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000009913; -.
DR   Ensembl; ENSOGAT00000011078; ENSOGAP00000009913; ENSOGAG00000011074.
DR   eggNOG; KOG3703; Eukaryota.
DR   eggNOG; ENOG410XQN4; LUCA.
DR   GeneTree; ENSGT00760000119023; -.
DR   InParanoid; H0X418; -.
DR   OMA; TNTIDYH; -.
DR   OrthoDB; EOG091G02CP; -.
DR   TreeFam; TF313193; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:Ensembl.
DR   GO; GO:0019213; F:deacetylase activity; IEA:Ensembl.
DR   GO; GO:0042328; F:heparan sulfate N-acetylglucosaminyltransferase activity; IEA:Ensembl.
DR   GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR   GO; GO:0003279; P:cardiac septum development; IEA:Ensembl.
DR   GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR   GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR   GO; GO:0030203; P:glycosaminoglycan metabolic process; IEA:Ensembl.
DR   GO; GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IEA:Ensembl.
DR   GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0006477; P:protein sulfation; IEA:Ensembl.
DR   GO; GO:0007585; P:respiratory gaseous exchange; IEA:Ensembl.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605; PTHR10605; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     18     39       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       25    518       HSNSD. {ECO:0000259|Pfam:PF12062}.
FT   DOMAIN      608    857       Sulfotransfer_1. {ECO:0000259|Pfam:
FT                                PF00685}.
SQ   SEQUENCE   885 AA;  101235 MW;  920091EE4C812FD1 CRC64;
     MPALACLRRL CRHVSPQAVL FLLFIFCLFS VFVSAYYLYG WKRGLEPSAD APEPDCGDPP
     PVAPSRLLPL KPVQAVAPSR TDPLVLVFVE SLYSQLGQEV VAILESSRFK YRTEIAPGKG
     DMPTLTDKGR GRFALIIYEN ILKYVNLDAW NRELLDKYCV AYGVGIIGFF KANENSLLSA
     QLKGFPLFLH SNLGLKDCSI NPKSPLLYVT RPSEVEKGVL PGEDWTVFQS NHSTYEPVLL
     AKTRSSESIP RVSSLLFLRL CFHALFPPEI SFPQGLSCLN FSIKTNFFLQ SILIAGSYAI
     WLGPGLNQPP LNRYIFMDMW QSRLGSVSPL ARGPVDEAVA LFDTQNELRT HIPNFTFNLG
     YSGKFFHTGT DAEDAGDDLL LSYVKEFWWF PHMWSHMQPH LFHNQSVLAE QMALNKKFAV
     EHGIPTDMGY AVAPHHSGVY PVHVQLYEAW KQVWSIRVTS TEEYPHLKPA RYRRGFIHNG
     IMVLPRQTCG LFTHTIFYNE YPGGSSELDK IINGGELFLT VLLNPISIFM THLSNYGNDR
     LGLYTFKHLV RFLHSWTNLR LQTLPPVQLA QKYFQIFSEE KDPLWQDPCE DKRHKDIWSK
     EKTCDRFPKL LIIGPQKTGT TALYLFLGLH PDLSSNYPSS ETFEEIQFFN GHNYHKGIDW
     YMEFFPIPSN TTSDFYFEKS ANYFDSEVAP RRAAALLPKA KVLTILINPA DRAYSWYQHQ
     RAHDDPVALK YTFHEVITAG PDASSKLRAL QNRCLVPGWY ATHIERWLSA FHANQILVLD
     GKLLRTEPAK VMDTVQKFLG VTNTIDYHKT LAFDPKKGFW CQLLEGGKTK CLGKSKGRKY
     PEMDLDSRAF LKDYYRDHNI ELSKLLYKIG QTLPTWLRED LQNTR
//
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