GenomeNet

Database: UniProt
Entry: H0X5Q8_OTOGA
LinkDB: H0X5Q8_OTOGA
Original site: H0X5Q8_OTOGA 
ID   H0X5Q8_OTOGA            Unreviewed;      2020 AA.
AC   H0X5Q8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   07-JUN-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSOGAP00000010635};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010635, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000010635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000010635}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000010635}.
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DR   EMBL; AAQR03111723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03111724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03111725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03111726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03111727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03111728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03111729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000010635; -.
DR   Ensembl; ENSOGAT00000011890; ENSOGAP00000010635; ENSOGAG00000011885.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0X5Q8; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    389    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    719    737       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    749    770       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    799       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    839    862       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    882    899       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    919    942       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1208   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1264       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1276   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1447   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1592   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1649   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1752   1775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    423       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      479    668       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      719    946       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      956   1203       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1207   1482       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1531   1785       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      414    445       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2020 AA;  228056 MW;  683FB1F1D6DF370F CRC64;
     MANFLLPRGT SSFRRFTRES LAAIEKRMVE KQARGSATSQ ESRDGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPI
     RRAAVKILVH SYPLHMLIMC TILTNCVFMA QHDPPPWTKY VEYTFTAIYT FESLVKILAR
     GFCLHAFTFL RDPWNWLDFS VIVMAYTTEF VDLGNVSALR TFRVLRALKT ISVISGLKTI
     VGALIQSVKK LADVMVLTVF CLSVFALIGL QLFMGNLRHK CVRNFTELNG TNGSVEADGL
     VWESLDDYLN NPENYLLKNG TSDVLLCGNS SDAGTCPEGY RCLKAGENPD HGYTSFDSFA
     WAFLALFRLM TQDCWERLYQ QTLRSAGKIY MIFFMLVIFL GSFYLVNLIL AVVAMAYEEQ
     NQATIAETEE KEKRFQEAME MLKKEHEALI IRSVDTMSRS SLEMSPLAPV TSHERRSKRR
     KRMSSGTEEC GEDRFPKSDS EDGPRAMNRL SLTHGLSRTS MKPRSSRGSI FTFRRRDLGS
     ETDFADDENS TAGESDSHRT SLLVPWPLRR PSAQGQPSPG TSAPGHALNG KRNSTVDCNG
     VVSLLGAGDP ETISPGSRLL HPMMLERPPD TTTPSEEPGG PQMLTPQAPC MDGFEEPGAR
     QRALSAVSVL TSALEELEES HRKCPPCWNR FAQRYLIWEC CPLWLSIKQK VKFLVTDPFA
     DLAITMCIVL NTLFMALEHY NMTAEFESML QVGNLVFTGI FTAEMTFKII ALDPYYYFQQ
     GWNIFDSIIV ILSLMELGLS RMNNLSVLRS FRLLRVFKLA KSWPTLNTLI KIIGNSVGAL
     GNLTLVLAII VFIFAVVGMQ LFGKNYSEQR HLISDSGLLP RWHMMDFFHA FLIIFRILCG
     EWIETMWDCM EVSGQSLCLL VFLLVMVIGN LVVLNLFLAL LLSSFSADNL TAPDEDGEMN
     NLQLALARIH RGLCFVKRTT WDFCCGLLRR RPQKPAALAS RSQLPSCIGT PGSPPPPEME
     KAPPARKETR FEEVKQPGQG TPGDPEPVCV PIAVAESDTD DQEEDEENSL GTEEESSKQQ
     ESQPVSGGPE ASPEPRTWSQ VSETASSEAE ASESQADWQQ QQKAEHQASG CSETQEDSYS
     EGSTADMTNT ADLLEQIPDL GEDVKDPEDC FTEGCVRRCP CCAVDTTQAP GKVWWRLRKT
     CYRIVEHSWF ETFIIFMILL SSGALAFEDI YLEDRKTVKV LLEYADKMFT YVFVLEMLLK
     WVAYGFKKYF TNAWCWLDFL IVDVSLISLV ANTLGFAEMG PIKSLRTLRA LRPLRALSRF
     EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GRFGRCINQT EGDLPLNYTI
     VNNKSECESF NVTGELYWTK VKVNFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRGYEEQ
     PQWEYNLYMY IYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKLGGQDIFM TEEQKKYYNA
     MKKLGSKKPQ KPIPRPLNKY QGFLFDIVTK QAFDVTIMFL ICLNMVTMMV ETDDQSPEKV
     SILAKINLLF VAIFTGECII KMTALRHYYF TNSWNIFDFV VVILSIMGTV LSDIIQKYFF
     SPTLFRVIRL ARIGRILRLI RGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMA
     NFAYVKWEAG IDDMFNFQTF ANSMLCLFQI TTSAGWDGLL SPILNTGPPY CDPNLPNSNG
     SRGNCGSPAV GILFFTTYII ISFLIVVNMY IAIILENFSV ATEESTEPLS EDDFDMFYEI
     WEKFDPEATQ FIEYSALSDF ADALSEPLRI AKPNQISLIN MDLPMVSGDR IHCMDILFAF
     TKRVLGESGE MDALKIQMEE KFMAANPSKI SYEPITTTLR RKHEEVSATV IQRAFRRHLL
     QRSMKHASFL FRQQVGSSGL SEEDAPEREG LIAYMMNENF SRPLSPPSSS SISSTSFPPS
     YDSVTRATSD NLQVRVSDYS RSEDLADFPP SPDRDRESIV
//
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