ID H0X791_OTOGA Unreviewed; 1219 AA.
AC H0X791;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=RNA binding motif protein 20 {ECO:0000313|Ensembl:ENSOGAP00000011268.2};
GN Name=RBM20 {ECO:0000313|Ensembl:ENSOGAP00000011268.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011268.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011268.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03046898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03046899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03046900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03046901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03046902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03046903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003787223.1; XM_003787175.1.
DR AlphaFoldDB; H0X791; -.
DR STRING; 30611.ENSOGAP00000011268; -.
DR Ensembl; ENSOGAT00000012582.2; ENSOGAP00000011268.2; ENSOGAG00000012579.2.
DR eggNOG; ENOG502QW62; Eukaryota.
DR GeneTree; ENSGT01030000234642; -.
DR HOGENOM; CLU_007364_0_0_1; -.
DR InParanoid; H0X791; -.
DR OMA; PTRADWG; -.
DR TreeFam; TF333921; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0097157; F:pre-mRNA intronic binding; IEA:Ensembl.
DR GO; GO:1990935; F:splicing factor binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0060914; P:heart formation; IEA:Ensembl.
DR GO; GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0033120; P:positive regulation of RNA splicing; IEA:Ensembl.
DR CDD; cd12685; RRM_RBM20; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR000690; Matrin/U1-C_Znf_C2H2.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034790; RBM20_RRM.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF11; RNA-BINDING PROTEIN 20; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00451; ZnF_U1; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50171; ZF_MATRIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 516..591
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1153..1184
FT /note="Matrin-type"
FT /evidence="ECO:0000259|PROSITE:PS50171"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..56
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..347
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1082..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1219 AA; 133379 MW; B66D93BDAD14C494 CRC64;
MVLAAAMSQD ADPSGPEQPD RDACSVSGAQ ASPVPSGPLG MQPPPPPPPP PPAGLPQIIQ
NAAKLLDKNP FSVGNPNPLL PSPASLQLAQ LQAQLTLHRL KLAQTAVTNN TAAATVLNQV
LSKVAMSQPL FNQLRHPSVI SSPHGHTGVP QHATTIPSTR FPSNAIGFSP PSQTRGPGPS
MGLPSQPPNA MVMHPFSGVM PQAPGQPAVI LGIGKTGPAP APAGFYEYGK ANSRQTYDSD
LDGQPSFLPA STSTSGNVSF EGHYSHTGQD GQIAFSKDPY GPNSQGPHVA GGFPPEQAGG
LQREVGPLLQ DADSQWESPH GFSGQGKPDL TAGPNLWPPP PSQPFELYDP EEPTSDRTPP
SFGGRLNNSK PGFGCARRRA KEEQAMLSMR PLQVHELNDL HGVAPLHLPH ICSICDKKVF
DLKDWELHVK GKLHTQKCLV FSENAGVRCI LGSAEGTLCA SPSSTALYNP AGSEDYASNL
GTPFAAIPAR SFAQSNPAFP LPSAGTNFAQ RKGAGRVVHI CNLPEGSCTE NDVINLGLPF
GKVTNYILMK STNQAFLEMA YTEAAQAMVQ YYQEKSAVIN GEKLLIRMSK RYKELQLKKP
GKTVAAIIQD IHSQRERDMF REAERYGPER PRSRSPVSRS LSPRSHTPSF TSCSSSHSPP
GPSRADWGNG RDSWEHSPYP RREEERDPAP WRENGEDKRD RMEPWAHDRK HHARQLDKAE
MEERLEGGRS HRERYPRSGS PNTLHSASIY KSREDSYYRK ELKAKSDKHL KQQQDAPGRS
RRKDEGKLRE SRHPHPDDSG KEEGLGPKVT RAPEGAKSKQ SEKNKTKRPD RDQEGADDRK
ERKMAENEAG KEEQEGVEES PQSVDRREKE TESSGLENTG TKKEQDWESG SEAEGESWYP
TNMEELVTVD EVGEEEDFIM EPDIPELEET VPIDEKDNLC PEICPCVTTT LEFTKEGVKA
MGNGAAEISL RSPRELPPIS TNCPSDMDVE MPGLNLDAER KPAESETGLS LEGSDCYEKE
AQGVESSDIH LAPAVPQMSS PKPAEEERAL QPSPFLEDCK ARGTPEDGAC EGSPLEEKAS
PRNEANIQSQ ACEEVTPENS RYMEVKSLDA RSPEYTEVEL KQPLSLPSWE PEDVFSELSI
PLGVEFVVPR TGFYCKLCGL FYTSEEMAKI SHCRSAVHYR NLQKYLSQLA EEGLKETEGA
GSPRPEDGGI VPRFERKKL
//
