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Database: UniProt
Entry: H0X802_OTOGA
LinkDB: H0X802_OTOGA
Original site: H0X802_OTOGA 
ID   H0X802_OTOGA            Unreviewed;      2323 AA.
AC   H0X802;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   SubName: Full=Calcium voltage-gated channel subunit alpha1 H {ECO:0000313|Ensembl:ENSOGAP00000011575};
GN   Name=CACNA1H {ECO:0000313|Ensembl:ENSOGAP00000011575};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011575, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000011575}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000011575}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000011575}.
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DR   EMBL; AAQR03077898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03077899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000011575; -.
DR   Ensembl; ENSOGAT00000012917; ENSOGAP00000011575; ENSOGAG00000012907.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0X802; -.
DR   OMA; QSSWNLL; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0032342; P:aldosterone biosynthetic process; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
DR   GO; GO:0035865; P:cellular response to potassium ion; IEA:Ensembl.
DR   GO; GO:0034651; P:cortisol biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000344; P:positive regulation of acrosome reaction; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    140    160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    232    255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    366    387       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    393    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    895    917       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    972    995       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1312   1333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1345   1371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1409   1431       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1510   1534       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1596   1613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1633   1652       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1731   1751       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1763   1783       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1818   1839       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    429       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      773   1000       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1272   1544       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1596   1848       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   2323 AA;  257237 MW;  1CF6B0374F09CDBF CRC64;
     MTEGALAADE VRVPLGAPPP GLAAAEASLA SPGVPGREGE RGSEPSASPP ESPVAERGVE
     LGTDEEQPVP YPALAATVFF CLGQTTRPRS WCLRLVCCTW FEHISMLVIM LNCVTLGMFR
     PCEDVECHSE RCAILEAFDD FIFAFFAVEM AIKMVALGLF GQKCYLGDTW NRLDFFIVMA
     GMMEYSLDGH NVSLSAIRTV RVLRPLRAIN RVPSMRILVT LLLDTLPMLG NVLLLCFFVF
     FIFGIVGVQL WAGLLRNRCF LDSTFVRNNN LTFLRPYYQT EEGEENPFIC SARRDNGMQK
     CSHIPGRREL RVPCTLGWEA YGQPLAEASS GTSHNACINW NQYYNVCRSG DSNPHNGAIN
     FDNIGYAWIA IFQVITLEGW VDIMYYVMDA HSFYNFIYFI LLIIVGSFFM INLCLVVIAT
     QFSETKQRES QLMREQRARH PSNDSTLASF SEPGSCYEEL LKYVGHIFRK VKRRSLRLCA
     RWQNRWRKKV DPSGALHGQG PGHRQRRAGG RAASVHHLVY HHHHHHHHHY HFSPSSPRGP
     GPEPGAGDTR LVRAGRPPSP PSPGHGPPDT ESVHSIYHAD CHVEGPQERA RVAHAAATAA
     ASLKLATGLG AMNYPTILPS GPNGGKGGTS PLPEGKQAGP HPYEKIQHVV GEHGLGRASS
     HLSGLSVPCP LPSPQAGTLT CELKNCPYCA SALEDPEFEF SGSESGDSDS RGVYEFTQDV
     QHSDHRDPVQ PPLEVGTPGQ GRPRRRVASG QPGRLGRLWA TFSCKLHRIV DSKYFNRGIM
     VAILINTLSM GVEHHEQPDE LTNALEISNI VFTSMFALEM LLKLLACGPL GYIRNPYNIF
     DGIIVVISVW EIVGQADGGL SVLRTFRLLR VLKLVRFLPA LRRQLVVLVK TMDNVATFCM
     LLMLFIFIFS ILGMHLFGCK FSLKTDTGDT VPDRKNFDTL LWAIVTVFQI LTQEDWNVVL
     YNGMASTSSW AALYFVALMT FGNYVLFNLL VAILVEGFQA EGDASRSDTD EDKTSTHFEE
     DFDKFRNLRT MEMKTYALAM TPNGPLEGRG SLPPPVIVRT AATPMPTPKS SPHLDPAPGP
     LGSRRGSDSS TEPQLGDQKS LASLHSSPCT PWGPNSAWSS RRSSWNSLGR APSLKRRSQR
     GERESLLSGE GKGSTDDEAD DSRPGEGART TPLRRTESLG HLPVDAALLP SKSHDCNGQT
     MALPSELFLR IDSHREDPAE CDEDMEASCC FRLHKVLEPY KPQWCRSRES WALYLFSPQN
     RLRVSCQRTI AHKMFDHVVL VFIFLNCITI ALERPDIDPG STERTFLSVS NYVFTAIFVA
     EMMMKVVALG LLAGEHAYLQ SSWNVLDGLL VLVSLVDIIV AMASAGGAKI LGVLRVLRLL
     RTLRPLRVIS RAPGLKLVVE TLISSLRPIG NIVLICCAFF IIFGILGVQL FKGKFYYCEG
     SDTRNISTKA ECWAAHYRWV RRKYNFDNLG QALMSLFVLS SKDGWVNIMY DGLDAVGVDQ
     QPVQNHNPWM LLYFISFLLI VSFFVLNMFV GVVVENFHKC RQHQEAEEAR RREEKRLQRL
     ERRRRSTFPN PEAQRRPYYA DYSPTRRSIH TLCTSHYLDL FITFIICVNV ITMSMEHYNQ
     PKSLDEALKY CNYVFTIVFV FEAALKLVAF GFRRFFKDRW NQLDLAIVLL SIVGIALEEI
     ETSAALPVNP TIIRIMRVLR IARVLKLLKM ATGMRALLDT VVQALPQVGN LGLLFMLLFF
     IYAALGVELF GRLECSEDNP CEGLSRHATF SNFGMAFLTL FRVSTGDNWN GIMKDTLREC
     TREDRHCLSY LPALSPVYFV TFVLVAQFVL VNVVVAVLMK HLEESNKEAR EDAEMDAEIE
     LEMAQGPPAR ADTDRPPSPQ ESPDTPSLLV VRKVSVSRML SLPNDSYMFR PVAPASARHP
     HPLQEVEMET YATYLPAPGT ATTAHSPPVE PHASLQVLSV MSSPAKGSSD ALHSPSPRGR
     PRSPSLSLLL CRQEAVHTES LKGHSDGLRD SILVSGEPEK TPVRQVSLGD SPEPTSIHTR
     KHTFGQHCIS SQPPAPGRDE AEAADPADEE VSHITSTAHT WQPPAEPHGL AKAGDEQALC
     SLYSVNTQGF LDEPGRADEQ RWPLAELGSG NHSPEPGEVK AQVLEAELTL GARRKKKMSP
     PCISVDPPAE DESSTRPPTV PGSTTLRRRT PSCEATPHRE SLEPAEVLGA GGDPAARGER
     WGQVPCRAEH LTVPSFAFRP LDLGGSEEDP FLDSGHTMAS EPRASASGTT APLEPQETEP
     PIPSGDPPEK RRGLYLTIPQ ASLKKPGSPP AAPAPGNGTD EPV
//
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