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Database: UniProt
Entry: H0X8X9_OTOGA
LinkDB: H0X8X9_OTOGA
Original site: H0X8X9_OTOGA 
ID   H0X8X9_OTOGA            Unreviewed;      1093 AA.
AC   H0X8X9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   SubName: Full=SEC24 homolog A, COPII coat complex component {ECO:0000313|Ensembl:ENSOGAP00000011972.2};
GN   Name=SEC24A {ECO:0000313|Ensembl:ENSOGAP00000011972.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011972.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000011972.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC       vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008334}.
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DR   EMBL; AAQR03009641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03009650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0X8X9; -.
DR   STRING; 30611.ENSOGAP00000011972; -.
DR   Ensembl; ENSOGAT00000013362.2; ENSOGAP00000011972.2; ENSOGAG00000013354.2.
DR   eggNOG; KOG1985; Eukaryota.
DR   GeneTree; ENSGT00950000182924; -.
DR   HOGENOM; CLU_004589_2_0_1; -.
DR   InParanoid; H0X8X9; -.
DR   OMA; MWRNNKM; -.
DR   TreeFam; TF350406; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0030127; C:COPII vesicle coat; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR   GO; GO:0090110; P:COPII-coated vesicle cargo loading; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd01479; Sec24-like; 1.
DR   Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR   Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR   Gene3D; 3.40.20.10; Severin; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR036180; Gelsolin-like_dom_sf.
DR   InterPro; IPR006900; Sec23/24_helical_dom.
DR   InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR   InterPro; IPR006896; Sec23/24_trunk_dom.
DR   InterPro; IPR012990; Sec23_24_beta_S.
DR   InterPro; IPR041742; Sec24-like_trunk_dom.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR006895; Znf_Sec23_Sec24.
DR   PANTHER; PTHR13803:SF1; PROTEIN TRANSPORT PROTEIN SEC24A; 1.
DR   PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR   Pfam; PF00626; Gelsolin; 1.
DR   Pfam; PF08033; Sec23_BS; 1.
DR   Pfam; PF04815; Sec23_helical; 1.
DR   Pfam; PF04811; Sec23_trunk; 1.
DR   Pfam; PF04810; zf-Sec23_Sec24; 1.
DR   SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR   SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR   SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          426..458
FT                   /note="Zinc finger Sec23/Sec24-type"
FT                   /evidence="ECO:0000259|Pfam:PF04810"
FT   DOMAIN          500..739
FT                   /note="Sec23/Sec24 trunk"
FT                   /evidence="ECO:0000259|Pfam:PF04811"
FT   DOMAIN          744..828
FT                   /note="Sec23/Sec24 beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF08033"
FT   DOMAIN          839..939
FT                   /note="Sec23/Sec24 helical"
FT                   /evidence="ECO:0000259|Pfam:PF04815"
FT   DOMAIN          965..1037
FT                   /note="Gelsolin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00626"
FT   REGION          1..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..220
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1093 AA;  120242 MW;  D81B4FDE273718DE CRC64;
     MSQPEMPASG GAPAGLQSQN GAASASGSPC TNGPVQNALM SSQVSGSQGY NFQLPGSYPH
     LIPAKTLNPA SGQSNYGSSQ GSGQTLNRPP VASNLVTPSL HSGLVSRMPL PASQNPAAAS
     MPSGSFLPGT NLPPPLNWQY NYPSTESQTN HSPRASSQPP VSGSTSSTTN HQYVSSGDPS
     LQNSFLKSGS SVPPLANPPL PTTFQPGAPH GPPPAGAPPL VRGLMPQKTS YRAVPQPSFN
     SATNQDGITS NTNNGSMVVH SSYDEIEGGG FLVWRAQAGF IPASSGVCGW CLSCLSYRRL
     TDFHIFKLIF PESKGWPGNL DYTFTPLGAN HLTASLSGLH LHPEGLRVVN LLQERNMLPS
     TPLQAPVPNL HEDIQKLNCN PELFRCTLTS IPQTQALLNK AKLPLGLLLH PFKDLVQLPV
     VTSSTIVRCR SCRTYINPFV SFLDQRRWKC NLCYRVNDAF KNFYLYALLS LVYYEPKRLQ
     RIMAITTYFC FKYVFVLRPP QPPVYLFVFD VSHNAVETGY LNSVCQSLLE NLDLLPGNTR
     TKIGFITFDS TIHFYSLQEG LSQPQMLIVS DIEDVFIPMP ENLLVNLNES KEKLVQDLLK
     TLPQMFTKTL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ LPSLGVGALK PREEPNQRSS
     AKEIHLTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA SLGCISRYSA GSVYYYPSYH
     HQHNPVQVQK LQKELQRYLT RKIGFEAVMR IRCTKGLSIH TFHGNFFVRS TDLLSLPNVN
     PDAGYAVQMS VEESLTDTQL VSFQSALLYT SSKGERRIRV HTLCLPVVST LNEIFLGADV
     QAISGLLANM AVDRSMTASL SDARDALVNA VIDSLSAYRS SVLSNQQPGL LVPFSLRLFP
     LFVLALLKQK SYVFNFDMSL NPHDFTESDI MTLPLKYILV AVWPGLALMF YLISQGALNI
     NDRTIPQPPI LQLSVEKLSR DGAFLMDAGS VLMLWVGKNC AHNFLSQVLG VQNYASIPQP
     MTDLPQLNTA ESARTIAFIS WLRDQRPFFP ILYVIRDESP MKANFLQNMV EDRTESALSY
     YEFLLHIQQQ VNK
//
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