ID H0X8X9_OTOGA Unreviewed; 1093 AA.
AC H0X8X9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=SEC24 homolog A, COPII coat complex component {ECO:0000313|Ensembl:ENSOGAP00000011972.2};
GN Name=SEC24A {ECO:0000313|Ensembl:ENSOGAP00000011972.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011972.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011972.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR EMBL; AAQR03009641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X8X9; -.
DR STRING; 30611.ENSOGAP00000011972; -.
DR Ensembl; ENSOGAT00000013362.2; ENSOGAP00000011972.2; ENSOGAG00000013354.2.
DR eggNOG; KOG1985; Eukaryota.
DR GeneTree; ENSGT00950000182924; -.
DR HOGENOM; CLU_004589_2_0_1; -.
DR InParanoid; H0X8X9; -.
DR OMA; MWRNNKM; -.
DR TreeFam; TF350406; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF1; PROTEIN TRANSPORT PROTEIN SEC24A; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 426..458
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 500..739
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 744..828
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 839..939
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 965..1037
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..220
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1093 AA; 120242 MW; D81B4FDE273718DE CRC64;
MSQPEMPASG GAPAGLQSQN GAASASGSPC TNGPVQNALM SSQVSGSQGY NFQLPGSYPH
LIPAKTLNPA SGQSNYGSSQ GSGQTLNRPP VASNLVTPSL HSGLVSRMPL PASQNPAAAS
MPSGSFLPGT NLPPPLNWQY NYPSTESQTN HSPRASSQPP VSGSTSSTTN HQYVSSGDPS
LQNSFLKSGS SVPPLANPPL PTTFQPGAPH GPPPAGAPPL VRGLMPQKTS YRAVPQPSFN
SATNQDGITS NTNNGSMVVH SSYDEIEGGG FLVWRAQAGF IPASSGVCGW CLSCLSYRRL
TDFHIFKLIF PESKGWPGNL DYTFTPLGAN HLTASLSGLH LHPEGLRVVN LLQERNMLPS
TPLQAPVPNL HEDIQKLNCN PELFRCTLTS IPQTQALLNK AKLPLGLLLH PFKDLVQLPV
VTSSTIVRCR SCRTYINPFV SFLDQRRWKC NLCYRVNDAF KNFYLYALLS LVYYEPKRLQ
RIMAITTYFC FKYVFVLRPP QPPVYLFVFD VSHNAVETGY LNSVCQSLLE NLDLLPGNTR
TKIGFITFDS TIHFYSLQEG LSQPQMLIVS DIEDVFIPMP ENLLVNLNES KEKLVQDLLK
TLPQMFTKTL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ LPSLGVGALK PREEPNQRSS
AKEIHLTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA SLGCISRYSA GSVYYYPSYH
HQHNPVQVQK LQKELQRYLT RKIGFEAVMR IRCTKGLSIH TFHGNFFVRS TDLLSLPNVN
PDAGYAVQMS VEESLTDTQL VSFQSALLYT SSKGERRIRV HTLCLPVVST LNEIFLGADV
QAISGLLANM AVDRSMTASL SDARDALVNA VIDSLSAYRS SVLSNQQPGL LVPFSLRLFP
LFVLALLKQK SYVFNFDMSL NPHDFTESDI MTLPLKYILV AVWPGLALMF YLISQGALNI
NDRTIPQPPI LQLSVEKLSR DGAFLMDAGS VLMLWVGKNC AHNFLSQVLG VQNYASIPQP
MTDLPQLNTA ESARTIAFIS WLRDQRPFFP ILYVIRDESP MKANFLQNMV EDRTESALSY
YEFLLHIQQQ VNK
//