ID H0X937_OTOGA Unreviewed; 1088 AA.
AC H0X937;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 8 {ECO:0000313|Ensembl:ENSOGAP00000012043.2};
GN Name=TRPM8 {ECO:0000313|Ensembl:ENSOGAP00000012043.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012043.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000012043.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAQR03182698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03182699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03182700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03182701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03182702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03182703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X937; -.
DR STRING; 30611.ENSOGAP00000012043; -.
DR Ensembl; ENSOGAT00000013447.2; ENSOGAP00000012043.2; ENSOGAG00000013442.2.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000160270; -.
DR HOGENOM; CLU_001390_0_0_1; -.
DR InParanoid; H0X937; -.
DR OMA; SLYCGRV; -.
DR TreeFam; TF314204; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR GO; GO:0050955; P:thermoception; IEA:Ensembl.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF9; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 693..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 955..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1025
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..365
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 743..989
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1088 AA; 125781 MW; BE785AA13384E5D9 CRC64;
MSFEAARLSM RKRRNGTLDS TRTLYSSMSR SIDLSYSESD FVNFIQANFK KRECVFFTKD
AKATESVCKC GYAQSHHIEG TQINQNEKWN YKKHTKEFPT DAFGDIQFES LGKKGKYIRL
SSDTDAEPLY ELLTQHWHLR TPNLVISVTG GAKNFALKPR MRKIISRLIY IAQTKGAWIL
TGGTHYGLMK YIGEVVRDNT ISRNSEENIV AIGIAAWGMV SNRDTLIRNC DAEGCFLAQY
IMDDFTRDPL YILDNNHTHL LLVDNGCHGH AAVEAKLRSQ LEKYISELTI PDSNYGGKIP
IVCFAQGGGK ETLKAINTSI KSKIPCVVVE GSGQIADVIA SLVEVEDALT LSIIKEKLVR
FLPRTVSRLP EEETENWIRW LKEILESSHL LTVIKMEEAG DEIVSNAISY ALYKAFSTNE
QDKDNWNGQL KLLLEWNQLD LANDEIFTND RRWESADLQE VMFTALIKDR PKFVRLFLEN
GLNLRKFLTH DVLTELFSSH FSTLVYRNLQ IAKNSYNDAL LTFVWKLVAN FRRGFRKEDR
NSRDDLDVEF HDVSPITRHP LQALFIWAIL QNKKELSKVI WEQTRGCTLA ALGASKLLKT
LAKVKNDINA AGESEELANE YETRAVELFT ECYSSDEDLA EQLLVYSCEA WGGSNCLELA
VEATDRHFIA QPGVQNFLSK QWYGEISRDT KNWKIILCLF IIPLVGCGFV SFRKKPLEKH
KKLLWYYVAF FTSPFVVFSW NVVFYIAFLL LFAYVLLMDF HTVPQPPELV LYALVFVLFC
DEVRQWYVNG VNYFTDLWNV MDTLGLFYFI AGIAFRLHNS NKSSLYSGRV IFCLDYIIFT
LRLIHIFTVS RNLGPKIIML QRMMIDVFFF LFLFAVWMVA FGVARQGILR QNEHRWRWIF
RSVIYEPYLA MFGQVPSDVD GTTYDFSHCT FTGNESKPLC VELDEHNLPR FPEWITIPLV
CIYMLSTNIL LVNLLVAMFG YTVGTVQENN DQVWKFQRYF LVQEYCSRLN IPFPFVVFAY
FYMVVKKCVG CCYRKRGAES SLCCFRNEDN ETLAWEGVMK ENYLVKINTK ANDTSEEMRH
RFRQLDTK
//
