ID   H0XAV7_OTOGA            Unreviewed;       511 AA.
AC   H0XAV7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Keratin 24 {ECO:0000313|Ensembl:ENSOGAP00000012784.2};
GN   Name=KRT24 {ECO:0000313|Ensembl:ENSOGAP00000012784.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012784.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000012784.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AAQR03042888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03042889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0XAV7; -.
DR   STRING; 30611.ENSOGAP00000012784; -.
DR   Ensembl; ENSOGAT00000014268.2; ENSOGAP00000012784.2; ENSOGAG00000014264.2.
DR   eggNOG; ENOG502QTM6; Eukaryota.
DR   GeneTree; ENSGT00940000161783; -.
DR   HOGENOM; CLU_012560_8_3_1; -.
DR   InParanoid; H0XAV7; -.
DR   OMA; SGSTNMG; -.
DR   TreeFam; TF332742; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF207; KERATIN, TYPE I CYTOSKELETAL 24; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   SUPFAM; SSF46579; Prefoldin; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          126..442
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          130..164
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          241..367
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        466..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  53880 MW;  0620F5BF15B6EDAD CRC64;
     SSRAGGSSSI RASTGGSSFN GSSKCSLGGG STRGFRGGTS CCGLSGGSSG GFGGSFGGGF
     GSCSVGAGFG GNSGYGASSA FGSGFGGSSG FGRGSGFASG AGGGFSSYGA GVGGGVGDGG
     LFSGGEKQTM QNLNDRLANY LDKVRALEEA NADLENKIKE WYDKLGPGSR DGVPGKDYSK
     YYAVIEDLRN QIITATTENA GIILQIDNAR LAADDFRLKY ENELHLRQSV EADINGLRKV
     LDDLTMTRSD LEMQVESLTE ELAFLKKNHE EEMRSMQGSS GGDVTVEMNA APGTDLTKLL
     NDMRAQYEEL AEQNRREAEE QFNKQSASLQ AQISTDAGAA TSARNEITEL KRTLQALEIE
     LQSQLAMKCS LEGTLADTEA GYVAQLSEIQ AKISSLEEQI CQVRGETECQ NSEYQQLLDI
     KTRLEKEIET YRCLLDGEGH GSCFGGFDYR KSGSRNMESR DVGAGDSRSG SCSGQGRDPS
     KTRVTKTIVE EVVDGKVVSS QVSSISEVKV K
//