ID H0XBE4_OTOGA Unreviewed; 578 AA.
AC H0XBE4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Ring finger and SPRY domain containing 1 {ECO:0000313|Ensembl:ENSOGAP00000013019.2};
GN Name=RSPRY1 {ECO:0000313|Ensembl:ENSOGAP00000013019.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013019.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013019.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03092869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XBE4; -.
DR STRING; 30611.ENSOGAP00000013019; -.
DR Ensembl; ENSOGAT00000014535.2; ENSOGAP00000013019.2; ENSOGAG00000014532.2.
DR eggNOG; KOG2242; Eukaryota.
DR GeneTree; ENSGT00940000157894; -.
DR HOGENOM; CLU_026400_0_0_1; -.
DR InParanoid; H0XBE4; -.
DR OMA; KYSHDSV; -.
DR TreeFam; TF313546; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16566; RING-HC_RSPRY1; 1.
DR CDD; cd12883; SPRY_RING; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR045129; RNF123/RSPRY1-like.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035774; SPRY_RSPRY1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13363:SF6; RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..578
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003545406"
FT DOMAIN 302..485
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 529..564
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 50..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 64790 MW; CD1E2392D44513F9 CRC64;
MIVFGWAVFL ASRSLGQGLL LTLGEHIAHF LGTRGATTIM GNSCICRDDS GAEDSVDTQQ
QQAENSALPA ADTRSQPRDP VRPPRRGRGP HEPRRKKQNV DGLVLDTLAV IRTLVDNDQE
PPYSMITLHE MAETDEGWLD VVQSLIRVIP LEDPLGPAVI TLLLDECPLP TKYEALSNKT
ESFFFLNMDL TSQARLEPAS SGVRGCRLTC LSHRRRGPAS IGLLSPGILE YLLQCLKLQS
HPTVMLFALI ALEKFAQTSE NKLTISESSI SDRLVTLESW ADDPDYLKRQ VGFCAQWSLD
NLFLKEGRQL TYEKVDLNGI TAMLNSNDVS EYLKISPHGL EARCDASSFE SVRCTFCVDA
GVWYYEVTVV TSGVMQIGWA TRDSKFLNHE GYGIGDDEYS CAYDGCRQLI WYNARSRPHQ
HPCWKEGDTV GFLLDLNEKQ MIFFLNGNRL PPEKQVFSST VSGFFAAASF MSYQQCEFNF
GAKPFKYPPS LKFSTFNDYA FLTAEEKIIL PRHRRLALLK QVSIRENCCS LCCDEVADTQ
LKPCGHSDLC MDCALQLETC PLCRKEIVSR VRQISHIS
//
