ID H0XBI0_OTOGA Unreviewed; 387 AA.
AC H0XBI0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Sorting nexin 7 {ECO:0000313|Ensembl:ENSOGAP00000013062.2};
GN Name=SNX7 {ECO:0000313|Ensembl:ENSOGAP00000013062.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013062.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013062.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4.
CC {ECO:0000256|ARBA:ARBA00038663}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AAQR03022774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XBI0; -.
DR STRING; 30611.ENSOGAP00000013062; -.
DR Ensembl; ENSOGAT00000014583.2; ENSOGAP00000013062.2; ENSOGAG00000014579.2.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00940000155315; -.
DR HOGENOM; CLU_040655_0_0_1; -.
DR InParanoid; H0XBI0; -.
DR OMA; LHYYEEC; -.
DR TreeFam; TF328543; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07284; PX_SNX7; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042130; PX_SNX7.
DR PANTHER; PTHR45949; SORTING NEXIN-4; 1.
DR PANTHER; PTHR45949:SF3; SORTING NEXIN-7; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 30..151
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 387 AA; 45389 MW; 1A7F53D68A769744 CRC64;
MDMNSFSPMM PTSPLSMINQ IKFEDEPDVK DLFITVDEPE SHVTTIETFI TYRIITKTSR
GEFDSSEFEV RRRYQDFLWL KGKLEEAHPT LIIPPLPEKF IVKGMVERFN EDFIETRRKA
LHKFLNRIAD HPTLTFNEDF KVFLTAQAWE LSSHKKQGPG LLSRMGQTVR AVASSMRGVK
SRPEEFMEMN TFIEMFSQKV NLIDKISQRI YKEEREYFDE MKEYGPIYIL WSASEDDLVD
ILKDVSSCID RCCKATEKRM AGLSEALLPV VHEYVLYSEM LMGVMKRRDQ IQAELESRLE
ALTYKKADTD LLTEEIGKLE DKVECANNAL KADWERWKLN MQNDLKSAFT DVAEENIHYY
EQVSQTEEYL INLDSDLFLR EDLDNNF
//
