GenomeNet

Database: UniProt
Entry: H0XCC8_OTOGA
LinkDB: H0XCC8_OTOGA
Original site: H0XCC8_OTOGA 
ID   H0XCC8_OTOGA            Unreviewed;      1699 AA.
AC   H0XCC8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSOGAP00000013430};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013430, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000013430}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000013430}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000013430}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAQR03118406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03118407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03118408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03118409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03118410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000013430; -.
DR   Ensembl; ENSOGAT00000015007; ENSOGAP00000013430; ENSOGAG00000015002.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0XCC8; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    121    140       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    184    205       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    239    262       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    371    399       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    530    553       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    565    583       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    604    625       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    645    673       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    735    757       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    987   1005       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1017   1034       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1076   1098       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1184   1210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1260   1287       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1324   1348       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1386   1413       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1490   1516       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1530   1565       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1699 AA;  195830 MW;  1489BCF55543BCB8 CRC64;
     MSASVEAKGL VPFTRESYEL IKQRIAKKHN EEHEEEDLKA DTDLEVGKKL PFIYGNLSQG
     MVSEPLEDVD PYYYKKKNTF IVLNRDRTIF RFNASSILCT LSPFSSIRGT TIKVLIHPRT
     LFRLLILISV LIDCIFMTMT DLPRWGPALE NTLLGIYTFE IIIKLFARGF WAGSFSFLGD
     PWNWLDFSVT LFEFITKCIP LNYILMLQKA RTLRILKIIP LNQGLQSRMG TLIHCLKKLM
     GAIILTLFFL SVFSLIGMGL FMGNLKHKCL WLPRENENET LHNRTGNPYY FRETEIFYYL
     EGEINALPCG NRTDAGQCPE GYVCVKAGLN PDRGFTNFDN FGWAFLALFR LMTQDFPENL
     YHQILYASGK VYMVFFVVVS FWFAFYMASL FLGILVMTYE EETQTATEKT NKTEPRFQEI
     EKELQEGNEA TEMKNIRYYK ELIDSYGQHE EKCINVHSYR SIKKRKKIPT YIVTVLKILS
     EXNLSNKSFI SELKKSKKKC PLCWYRIAKL FLIWDCSPCW LKLKEFVHRI IMYPFTDLVL
     ALCIILNVCF LALEHYPMSE EINSLLSIGN LVFIGIFTAE MILKIIAMHP YEYFQVGWNI
     FDSVIVFLGL TELYLANIQG IYYFRLFRML RIFKLGKYWP TFENLMLTLT NSVAALEDLV
     LLLFTFIFFS AVLGMKLFGQ SYREGVCHID KDCQAPRWHM YDFFHSFLNV FRMLCGEWIE
     TLWDCMEVAG RPWCISFYMM VILIGNLLIL YLFLALVSSF RSHNAVTTEK NDETKNLQLA
     LTRIQTGISH VFLKILCKKQ NIPKERLDHA LSELSNTQDF LTDKEKHSGT EKTTVTENES
     QSPLPSPSVS ETVPIASGES DIENVDNKEI QSKSGDGGSK EKIKPSSSSE CSTVDIAISE
     EEEMVCEHDR PKHLKNDDRR TSSLGQISRE SKKGKMWQNI RKTCSKIVEN EWFKCFIGLV
     TLLSTGALAF EDIYIDQRKT IKILLEYADM IFTYIFILEM LLKWMAYGFK AYFSNGWYKL
     DFMVVIVFCL SLIGKSREEL KPLTSIKFLR ALRVLSQFER MKVVVKALIK TTFPALNVFL
     VCLLIWLAFS IMGVNLFAGK FYECIDPTSG ERFPVSKVAN KSECEGLVFN ESVPWKNAKL
     NFDNVGNGFL SLLQVATFNG WIDIMNSAVD SVEVNMQPDF EFSIYMYCYF INFIIFGLFI
     PLSMLISVII TSFNKYKIQQ GGPNIFITGQ QRKQYRVLKK LMCEDSQRPI PRPRNKFQGF
     IFDLVTNPVF NVIIMVIICL HTIILMIQSD EQGPEKEIAF YWINSTVVML YAIECVLKLI
     SFHCYYFTIG WNIFDFMVVI FSTTGLLLPM TVGYSIVPPS LVQLILLARI VHVLRLGKGP
     KVFHDLMLPF VLSLPALLNI GLLIFLLMFV YAICGMYNFA YVKKEAGIND VSNFETFVSS
     MLCLFQVTIF AGWDGMLKAI FRSEWSDCDP DKINPGTQVR GDCGSPSVGI LYFVSYILLS
     WLVIVNMYIV VVMEFLNISS KKKVKTLSED DFKRFFQVWK RFDPDRTQYI DSSKLSDFAA
     SLDPPLFMAK PNKSQLLALD LPMAVGDRIH CLDILLAFTK RVVGNDARVE KVLSEIESGF
     LLANPFKITY EPITSTLKRK QEAVSARIIQ RAYKNYRLRQ QDKNTIDIRK IDADRDVQAP
     KEGVYSDKAE EKSTVQSQS
//
DBGET integrated database retrieval system