ID H0XDW9_OTOGA Unreviewed; 81 AA.
AC H0XDW9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=cAMP-dependent protein kinase inhibitor {ECO:0000256|PIRNR:PIRNR001667};
GN Name=PKIB {ECO:0000313|Ensembl:ENSOGAP00000014091.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014091.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014091.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent
CC protein kinase activity, this protein interacts with the catalytic
CC subunit of the enzyme after the cAMP-induced dissociation of its
CC regulatory chains. {ECO:0000256|ARBA:ARBA00002844}.
CC -!- SIMILARITY: Belongs to the PKI family. {ECO:0000256|ARBA:ARBA00006393,
CC ECO:0000256|PIRNR:PIRNR001667}.
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DR EMBL; AAQR03004370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XDW9; -.
DR STRING; 30611.ENSOGAP00000014091; -.
DR Ensembl; ENSOGAT00000015732.2; ENSOGAP00000014091.2; ENSOGAG00000015729.2.
DR eggNOG; ENOG502S8BW; Eukaryota.
DR GeneTree; ENSGT00530000064264; -.
DR HOGENOM; CLU_163471_1_0_1; -.
DR InParanoid; H0XDW9; -.
DR OMA; YQDVAMR; -.
DR TreeFam; TF330809; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IEA:UniProtKB-UniRule.
DR GO; GO:1904355; P:positive regulation of telomere capping; IEA:Ensembl.
DR GO; GO:0032212; P:positive regulation of telomere maintenance via telomerase; IEA:Ensembl.
DR InterPro; IPR004171; cAMP_dep_PKI.
DR PANTHER; PTHR15416:SF6; CAMP-DEPENDENT PROTEIN KINASE INHIBITOR BETA; 1.
DR PANTHER; PTHR15416; CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI; 1.
DR Pfam; PF02827; PKI; 1.
DR PIRSF; PIRSF001667; PKI; 1.
PE 3: Inferred from homology;
KW Protein kinase inhibitor {ECO:0000256|PIRNR:PIRNR001667};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 26
FT /note="Important for inhibition"
FT /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
FT SITE 29
FT /note="Important for inhibition"
FT /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
FT SITE 30
FT /note="Important for inhibition"
FT /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
SQ SEQUENCE 81 AA; 8686 MW; A71F446C832BFDCE CRC64;
DVAMKTDPPK MTDVESGVPN FASSSRAGRR NAVPDIQSSA ATSGTSDLPL KLEALSVKED
VKKKDEETTQ DQPEKPQNEG K
//
