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Database: UniProt
Entry: H0XF95_OTOGA
LinkDB: H0XF95_OTOGA
Original site: H0XF95_OTOGA 
ID   H0XF95_OTOGA            Unreviewed;      2336 AA.
AC   H0XF95;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSOGAP00000014671};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014671, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000014671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000014671}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000014671}.
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DR   EMBL; AAQR03116257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03116266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000014671; -.
DR   Ensembl; ENSOGAT00000016395; ENSOGAP00000014671; ENSOGAG00000016377.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H0XF95; -.
DR   OMA; DSPRNNA; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    138    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    303    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    336    358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    613    635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    691    713       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1152   1170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1190   1210       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1222   1240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1283   1305       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1395   1420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1476   1494       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1506   1529       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1541   1565       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1586   1615       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1684   1707       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1723   1758       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      716    742       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2336 AA;  261335 MW;  FFAF97E01C1568FE CRC64;
     MVRFGDELGG RYGGAGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA QRARTMALYN
     PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPHTPF EYMILATIIA NCIVLALEQH
     LPDGDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFVFH KGSYLRNGWN VMDFVVVLTG
     ILATAGTDFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMVPLLQIG LLLFFAILMF
     AIIGLEFYMG KFHKACFPNS TDTDPVGDFP CGKEPPARLC EGDTECREYW PGPNFGITNF
     DNILFAVLTV FQCITMEGWT DILYNTNDAA GNTWNWLYFI PLIIIGSFFM LNLVLGVLSG
     EFAKERERVE NRRAFLKLRR QQQIERELNG YLEWIFKAEE VMLAEEDRNA EEKSPLDAVL
     KRAAAKKSRN DLIHAEEGED RFADLCAVGS PFARASLKSG KTESSSYFRR KEKLFRFFIR
     RVVKAQSFYW AVLCVVALNT LCVAMVHYNQ PQRLTTALYF AEFVFLGLFL TEMSLKMYGL
     GPRSYFRSSF NCFDFGVIVG SIFEVVWAAI KPGASFGISV LRALRLLRIF KVTKYWSSLR
     NLVVSLLNSM KSIVSLLFLL FLFIVVFALL GMQLFGGQFN FKDETPTTNF DTFPAAILTV
     FQILTGEDWN AVMYHGIESQ GGVSKGMFSS FYFIVLTLFG NYTLLNVFLA IAVDNLANAQ
     ELTKDEEEME EAANQKLALQ KAKEVAEVSP MSAANISIAA RQQNSAKARS VWEQRASQLR
     LQNLRASCEA LYSELDPEER LRFATTRHLR PDMKTHLDRP LVVELGRDGP RAPPGGKARP
     EATDATEGAD PPRRHHRHRD RDKAAAGEPD RADAPRAESG EPSARDERVR PHRSHSKEAA
     GPPEARGERG RGPGPEGGRR HHRRGSLEEA TDREPRRHRA HRHACDQGKE GSAPTAKGER
     RSRHRGGPRA GPREAESGEE PARRHRTRHK VLPAQDAAVK EAPEKEAEVA EVDKEKELRN
     HQPKELHCDL EASGTMGVGP VHTLPSTCLQ KVEEQPEDAD NQRNVTRMSS QPSDPSTTVH
     IPVTLTGPPG ETTVVSSGNV DPESQVEGKK EVEADDVMRS GPRPIVPYSS MFCLSPTNLL
     RRLCHYIVTM RYFEMVILVV IALSSIALAA EDPVRTDSPR NNALKYMDYI FTGVFTFEMV
     IKMIDLGLLL HPGAYFRDLW NILDFIVVSG ALVAFAFSGS KGKDINTIKS LRVLRVLRPL
     KTIKRLPKLK AVFDCVVNSL KNVLNILIVY MLFMFIFAVI AVQLFKGKFF YCTDESKELE
     RDCRGQYLDY EKEEVEAQPR QWKKYDFHYD NVLWALLTLF TVSTGEGWPM VLKHSVDATY
     EEQGPSPGYR MELSIFYVVY FVVFPFFFVN IFVALIIITF QEQGDKVMSE CSLEKNERAC
     IDFAISAKPL TRYMPQNKQS FQYKTWTFVV SPPFEYFIMA MIALNTAVLM MKFYDAPYEY
     ELMLKCLNIV FTSMFSMECV LKIIAFGVLN YFRDAWNVFD FVTVLGSITD ILVTEIANNF
     INLSFLRLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY VCLLIAMLFF IYAIIGMQVF
     GNIALDDDTS INRHNNFQTF LQALMLLFRS ATGEAWHEIM LSCLSNRACD ERASASECGS
     DFAYFYFVSF IFLCSFLMLN LFVAVIMDNF EYLTRDSSIL GPHHLDEFIR VWAEYDPAAC
     GRISYNDMFE MLKHMSPPLG LGKKCPARVA YKRLVRMNMP ISSEDMTVHF TSTLMALIRT
     ALEIKLAPAG TKQHQCDAEL RKEISVVWAN LPQKTLDLLV PPHKPDEMTV GKVYAALMIF
     DFYKQNKTTR DQIQAPGGLS QMGPVSLFHP LKATLEQTQP AVLRGARVFL RQKSSTSLSN
     GGAIQTQESG IKESVSWGTQ RTQDTPCEAW APLERGHSAE IPAMQPGVLA VDVQMQNMAM
     RAPNGDPQPG LESQGRAASM PRLAAETQPV PDASPMKRSI STLAQRPHAA HLCSTALDRP
     PPSQASHHHH HRCHRRRDKK QRPLEKGPSL SADVDGATGS AAGPGLPPGE GPASCRRERE
     RRQERGRSQE RRQPSSSSSE KQRFYSCDRF GGREPPKPKL SLSSHPTSPT AGQEPGPHPK
     GSGSVNGSPL PSASGASTPG RGGRRQLPQT PPTPRPSVTY KTANSSPVHF SGAQTSLPAF
     SPGRLSRGLS EHNALLQTDP LGPPLVPSSR IGSDPYLGQR LDSEASAHTL PEDTLTFEEA
     LATNSGRSSR TSYVSSLTSQ SHPLRRVPNG YHCTLGLSSG GRARHSYHHP DQDHWC
//
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