GenomeNet

Database: UniProt
Entry: H0XFB5_OTOGA
LinkDB: H0XFB5_OTOGA
Original site: H0XFB5_OTOGA 
ID   H0XFB5_OTOGA            Unreviewed;      1656 AA.
AC   H0XFB5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   30-AUG-2017, entry version 40.
DE   SubName: Full=Sodium voltage-gated channel alpha subunit 1 {ECO:0000313|Ensembl:ENSOGAP00000014694};
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSOGAP00000014694};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014694, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000014694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000014694}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000014694}.
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DR   EMBL; AAQR03118363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03118364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03118365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000014694; -.
DR   Ensembl; ENSOGAT00000016423; ENSOGAP00000014694; ENSOGAG00000016402.
DR   eggNOG; ENOG410KCTY; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0XFB5; -.
DR   OMA; CMSNHTT; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0043194; C:axon initial segment; IEA:Ensembl.
DR   GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0033268; C:node of Ranvier; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Ensembl.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0019227; P:neuronal action potential propagation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR01664; NACHANNEL1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    191    210       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    249    269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    398    425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    759    783       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    795    816       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    878    906       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    965    991       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1217   1235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1256   1275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1331   1359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1457   1481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1540   1558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1570   1588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1600   1620       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      126    432       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      504    717       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      768    995       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1005   1211       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1215   1489       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1539   1656       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      422    460       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1656 AA;  188952 MW;  9267434F91B526C6 CRC64;
     MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KNDDENGPKP NSDLEAGKNL
     PFIYGDVPPG MVSEPLEDLD PYYVNKKTFI VLNKGKAIFR FSATSALYIL TPFNPLRKIA
     IKILVHSLFS MLIMCTILTN CVFMTMSNPP DWTKNVEYTF TGIYTFESLI KIIARGFCLE
     DFTFLRDPWN WLDFTVITFA YVTEFVDLGN VSALRTFRVL RALKTISVIP GLKTIVGALI
     QSVKKLSDVM ILTVFCLSVF ALIGLQLFMG NLRNKCVQWP PTNASLEEHS IENNITVDYN
     GTLVNETVVK FDWKSYIQDS RYHYFLEGFP DALLCGNSSD AGQCPEGYMC VKAGRNPNYG
     YTSFDTFSWA FLSLFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFLGS FYLINLILAV
     VAMAYEEQNQ ATMEEAEQKE AEFQQMLEQL KKQQEAAQQA ATVTASEHSR EPSAAGRLSD
     SSSEASKLSS KSAKERRNRR KKRKQKEQSG GEEKDDDEFH KSESEDSIRR KGFRFSIEGN
     RLTYEKRYSS PHQSLLSIRG SLFSPRRNSR TSLFSFRGRA KDVGSENDFA DDEHSTFEDN
     ESRRDSLFVP RRHGERRNSN LSQTSRSSRM LAVLPANGKM HSSVDCNGVV SLVGGPSVPT
     SPVGQLLPEV IIDKPATDDN GTTTETEMRK RRSSSFHASM DFLEDPSQRQ RAMSIASILT
     NTVEELEESR QKCPPCWYKF SNIFLIWDCS PYWLKVKHIV NLVVMDPFVD LAITICIVLN
     TLFMAMEHYP MTEHFNNVLA VGNLVFTGIF TAEMFLKIIA MDPYYYFQEG WNIFDGFIVT
     LSLVELGLAD VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV
     FIFAVVGMQL FGKSYKDCVC KISSDCELPR WHMHDFFHSF LIVFRVLCGE WIETMWDCME
     VAGQAMCLTV FMMVMVIGNL VVLNLFLALL LSSFSADNLA ATDDDNEMNN LQIAVDRIQK
     GIDYVKRKIY EFIQQSFVRK QKILDEIKPL DDLNNRKDCM SNHTTEIGKD LDYLKDVNGT
     TSGIGTGSSV EKYIIDESDY MSFIHNPSLT VTVPIAVGES DFENLNTEDF SSESDLEESK
     EKLNESSSSS EGSTVDIGAP AEEQPVVEPE EALEPEACFT EGCVQRFKCC QISVEEGRGK
     QWWNLRRTCF RIVEHNWFET FIVFMILLSS GALAFEDIYI DQRKTIKTML EYADKVFTYI
     FILEMLLKWV AYGYQTYFTN AWCWLDFLIV DVSLVSLTAN ALGYSELGAI KSLRTLRALR
     PLRALSRFEG MRVVVNALLG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK FYHCINTTTG
     DRFDITEVNN HSDCLKLIER NETARWKNVK VNFDNVGFGY LSLLQVATFK GWMDIMYAAV
     DSRNVELQPK YEESLYMYLY FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK FGGQDIFMTE
     EQKKYYNAMK KLGSKKPQKP IPRPGNKFQG MVFDFVTRQV FDISIMILIC LNMVTMMVET
     DDQSEYVTTI LSRINLVFIV LFTGECVLKM ISLRHYYFTI GWNIFDFVVV ILSIVGMFLA
     ELIEKYFVSP TLFRVIRLAR IGRILRLIKG AKGIRT
//
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