GenomeNet

Database: UniProt
Entry: H0XGR2_OTOGA
LinkDB: H0XGR2_OTOGA
Original site: H0XGR2_OTOGA 
ID   H0XGR2_OTOGA            Unreviewed;      4867 AA.
AC   H0XGR2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   30-AUG-2017, entry version 41.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSOGAP00000015279};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSOGAP00000015279};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015279, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000015279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000015279}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000015279}.
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DR   EMBL; AAQR03159218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03159227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000015279; -.
DR   Ensembl; ENSOGAT00000017067; ENSOGAP00000015279; ENSOGAG00000017046.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H0XGR2; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4175   4194       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4398   4418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4472   4491       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4608   4629       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4666   4687       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4742   4767       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        9     64       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       71    116       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      124    179       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      185    242       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      250    307       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      498    708       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      924   1121       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1236   1460       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3922   3957       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4315   4337       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4867 AA;  553311 MW;  AC5BF58F7AE14AE5 CRC64;
     MKTAQGGGHR TLLYGHAILL RHSYSGMYLC CLSTSRSSTD KLAFDVGLQE DTTGEACWWT
     IHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSYGNGSL HVDAAFQQTL WSVAPISSGS
     EAAQGYLIGG DVLRLLHGHM DECLTVPSGE HGEEQRRTVH FEGGAISVHA RSLWRLETLR
     VAWSGSHIRW GQPFRLRHVT TGKYLSLMED KTLLLMDKEK ADVKSTAFTF RSSKEKLDVG
     VRKEVDGMGT SEIKYGDSVC FIQHVDTGLW LTYQSVDVKS VRMGSIQRKA IMHHEGHMDD
     GLNLSRSQHE ESRTARVIRS TVFLFNRFIR GLDALSKKVK PSTVDLPIES VSLSLRDLIG
     YFHPPDEHLE HEDKQNRLRA LKNRQNLFQE EGMISLVLEC IDRLHVYSSA AHFADVAGRE
     AGESWKSILN SLYELLAALI RGNRKNCAQF SGSLDWLISR LERLEASSGI LEVLHCVLVE
     SPEALNIIKE GHIKSIISLL DKHGRNHKVL DVLCSLCVCH GVAVRSNQHL ICDNLLPGRD
     LLLQTRLVNH VSSMRPNIFL GVSEGSAQYK KWYYELMVDH TEPFVTAEAT HLRVGWASTE
     GYSPYPGGGE EWGGNGVGDD LFSYGFDGLH LWSGCIARTV SSPNQHLLRT DDVISCCLDL
     STPSISFRIN GQPVQGMFEN FNIDGLFFPV VSFSAGIKVR FLLGGRHGEF KFLPPPGYAP
     CYEAVLPKEK LKVEHSREYK QERSYTRDLL GPTVSLTQAA FTPIPVDTTQ IVLPPHLERI
     REKLAENIHE LWVMNKIELG WQYGPVRDDN KRQHPCLVEF SKLPEQERNY NLQMSLETLK
     TLLALGCHVG ISDEHAEEKV KKMKLPKNYQ LTSGYKPAPM DLSFIKLTPS QEAMVDKLAE
     NAHNVWARDR IRQGWTYGIQ QDVKNRRNPR LVPYTLLDDR TKKSNKDSLR EAVRTLLGYG
     YHLEAPDQDH AARAEVCSGT GERFRIFRAE KTYAVKAGRW YFEFEAVTAG DMRVGWSRPG
     CQPDQELGSD ERAFAFDGFK AQRWHQGNEH YGRSWQAGDV VGCMVDMNEH TMMFTLNGEI
     LLDDSGSELA FKDFDVGDGF IPVCSLGVAQ VGRMNFGKDV STLKYFTICG LQEGYEPFAV
     NTNRDITMWL SKRLPQFLQV PSNHEHIEVT RIDGTIDSSP CLKVTQKSFG SQNSSSDIMF
     YRLSMPIECA EVFSKTVPGG LPGAGLFGPK NDLEDYDADS DFEVLMKTAH GHLVPGVDKD
     KETTKPEFNN HKDYAQEKPS RLKQRFLLKR TKPDYSTSHS ARLTEDVLAD DRDDYDYLMQ
     TSTYYYSVRI FPGQEPANVW VGWITSDFHQ YDTGFDLDRV RTVTVTLGDE KGKVHESIKR
     SNCYMVCAGE NMSPGQGRNN NGLEIGCVVD AASGLLTFIA NGKELSTYYQ VEPSTKLFPA
     VFAQATSPNV FQFELGRIKN VMPLSAGLFK SEHKNPVPQC PPRLHVQFLS HVLWSRMPNQ
     FLKVDVSRIS ERQGWLVQCL DPLQFMSLHI PEENRSVDIL ELTEQEELLK FHYHTLRLYS
     AVCALGNHRV AHALCSHVDE PQLLYAIENK YMPGLLRAGY YDLLIDIHLS SYATARLMMN
     NEFIVPMTEE TKSITLFPDE NKKHGLPGIG LSTSLRPRMQ FSSPSFVSIN NECYQYSPEF
     PLDILKAKTI QMLTEAVKEG GLHARDPVGG TTEFLFVPLI KLFYTLLIMG VFHNEDLKHI
     LQLIEPSVFK EAATGEEESD TPEKELSAED SKLEGASEEE AKGGKRPKEG LLQMKLPEPV
     KLQMCLLLQY LCDCQVRHRI EAIVAFSDDF VAKLQDNQRF RYNEVMQALN MSAALTARKT
     KEFRSPPQEQ INMLLNFKDD KSECPCSEEI RDQLLDFHED LMTHCGIELD EDGSLDGNSD
     LTIRGRLLSL VEKVTYLKKK QAEKPIESDL RKSSTLQQLI SETMVRWAQE SVIEDPELVR
     AMFALLHRQY DGIGGLVRAL PKTYTINGVS VEDTIKLLAS LGQIRSLLSV RMGKEEEQLM
     IHGLGDIMNN KVFYQHPNLM RALGMHETVM EVMVNVLGGG ESKEITFPKM VANCCRFLCY
     FCRISRQNQK AMFDHLSYLL ENSSVGLASP AMRGSTPLDV AAASVMDNNE LALALREPDL
     EKVVRYLAGC GLQSCQMLVC KGYPDIGWNP VEGERYLDFL RFAVFCNGES VEENANVVVR
     LLIRRPECFG PALRGEGGNG LLAAMEEAIK IAEDPSRDGP SPNSGSSKTL KKEGAEEDWI
     DLGTAIVTIF YIFNLDHTGR CTPEGPLIHA GKGEAIRIRS ILRSLIPLGD LVGVISIPFQ
     MPTVAKDGNV VEPDMSAGFC PDHKAAMVLF LDRVYGIEVQ DFLLHLLEVG FLPDLRAAAS
     LDTAALSATD MALALNRYLC TAVLPLLTRC APLFAGTEHH ASLIDSLLHT VYRLSKGCSL
     TKAQRDSIEV CLLSICGQLR PSMMQHLLRR LVFDVPLLNE HAKMPLKLLT NHYERCWKYY
     CLPGGWGNFG AASEEELHLS RKLFWGIFDA LSQKKYEQEL FKLALPCLSA VAGALPPDYM
     ESNYVSMMEK QSSMDSEGNF NPQPVDTSNI TIPEKLEYFI NKYAEHSHDK WSMDKLANGW
     IYGEIYSDSS KVQPLMKPYK LLSEKEKEIY RWPIKESLKT MLAWGWRIER TREGDSMALY
     NRTRRISQTS QVSVDAAHGY SPRAIDMSNV TLSRDLHAMA EMMAENYHNI WAKKKKMELE
     SKGGGNHPLL VPYDTLTAKE KAKDREKAQD ILKFLQINGY VVSRGFKDLE LDTPSIEKRF
     AYSFLQQLIR YVDEAHQYIL EFDGGSRVKG EHFPYEQEIK FFAKVVLPLI DQYFKNHRLY
     FLSAASRPLC SGGHASNKEK EMVTSLFCKL GVLVRHRISL FGNDATSIVN CLHILGQTLD
     ARTVMKTGLE SVKSALRAFL DNAAEDLEKT MENLKQGQFT HTRNQPRGVT QIINYTTVAL
     LPMLSSLFEH IGQHQFGEDL ILEDVQVSCY RILTSLYALG TSKSIYVERQ RSALGECLAA
     FAGAFPVAFL ETHLDKHNSY SIYNTKSSRE RAALSLPASV EDVCPNIPSL EKLMEEIVEL
     AESGIRYTQM PHVMEVILPM LCSYMSRWWE HGPENNPERA EMCCTALNSE HMNTLLGNIL
     KIIYNNLGID EGAWMKRLAV FSQPIINKVK PQLLKTHFLP LMEKLKKKAA LVVSEEEHMK
     AEARGDMSEA ELLILDEFTT LARDLYAFYP LLIRFVDYNR AKWLKEPNPE AEELFRMVAE
     VFIYWSKSHN FKREEQNFVV QNEINNMSFL ITDTKSKMSK AAVSDQERKK MKRKGDRYSM
     QTSLIVAALK RLLPIGLNIC APGDQELIAL AKNRFSLKDT EDEVRDIIRS NIHLQGKLED
     PAIRWQMALY KDLPNRTDDP ADPEKTVERV LDIANVLFHL EQKSKNTNWR YYSLVEHPQR
     SKKAVWHKLL SKQRKRAVVA CFRMAPLYNL PRHRAVNLFL QGYEKSWIET EEHYFEDKLI
     EDLAKPGAEP PEEDEGAKRV DPLHQLILLF SRTALTEKCK LEEDFLYMAY ADIMAKSCHD
     EEDDDGEEEV KSFEEKEMEK QKLLYQQARL HDRGAAEMVL QTISASKGET GPMVAATLKL
     GIAILNGGNS TVQQKMLDYL KEKKDVGFFQ SLAGLMQSCS VLDLNAFERQ NKAEGLGMVT
     EEGSGEKVLQ DDEFTCDLFR FLQLLCEGHN SDFQNYLRTQ TGNNTTVNII ISTVDYLLRV
     QESISDFYWY YSGKDVIDEQ GQRNFSKAIQ VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW
     DAVVGFLHVF AHMQMKLSQD SSQIELLKEL MDLQKDMVVM LLSMLEGNVV NGTIGKQMVD
     MLVESSNNVE MILKFFDMFL KLKDLTSSDT FKEYDPDGKG VISKRDFHKA MESHKHYTQS
     ETEFLLSCTE MDENETLDYE EFVKRFHEPA KDIGFNVAVL LTNLSEHMPN DTRLQTFLEL
     AESVLNYFQP FLGRIEIMGS AKRIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG
     EKEKMELFVN FCEDTIFEMQ LAAQISESDL NERSANKEES EKERPEEQGP RMGFFSILTV
     KSALLALRCN VLTLIRMLSI KSLKKQMKKM KKMTVKDMVT AFFCSYWSLF MTLLHFVASV
     FRGFCRIVCS LLLGASLVEG AKKIKVAELL ANMPDPTQDE VRGDGEEGER KPMEAALPSE
     DLADLKELTE ESDLLSDIFG LDLKREGGQY KLIPHNPNAG LSDLMSNPVP IPEVQEKFQE
     QKAKDEEKEE KEETKSEPEK AEGEDGEKEK PRDDKSKQKL RQLHTHRYGE PEVPESAFWK
     KIIAYQQKLL NYFARNFYNM RMLALFVAFA INFILLFYKV STSSVVEGKE LPPRSSSENT
     RVTSLDSSSP RVIAVHYVLE ESSGYMEPTL RILAILHTVI SFFCIIGYYC LKVPLVIFKR
     EKEVARKLEF DGLYITEQPS EDDIKGQWDR LVINTQSFPN NYWDKFVKRK VMDKYGEFYG
     RDRISELLGM DKAALDFSDA REKKKPKKDS SLSAVLNSID VKYQMWKLGV VFTDNSFLYL
     AWYMTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT
     VVAFNFFRKF YNKSEDGDTP DMKCDDMLTC YMFHMYVGVR AGGGIGDEIE DPAGDEYEIY
     RIIFDITFFF FVIVILLAII QALGLIIDAF GELRDQQEQV KEDMETKCFI CGIGNDYFDT
     VPHGFETHTL QEHNLANYLF FLMYLINKDE TEHTGQESYV WKMYQERCWE FFPAGDCFRK
     QYEDQLN
//
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