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Database: UniProt
Entry: H0XGX3_OTOGA
LinkDB: H0XGX3_OTOGA
Original site: H0XGX3_OTOGA 
ID   H0XGX3_OTOGA            Unreviewed;       839 AA.
AC   H0XGX3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   07-JUN-2017, entry version 28.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A4 {ECO:0000313|Ensembl:ENSOGAP00000015346};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015346, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000015346}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000015346}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000015346}.
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DR   EMBL; AAQR03083453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000015346; -.
DR   Ensembl; ENSOGAT00000017136; ENSOGAP00000015346; ENSOGAG00000017130.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H0XGX3; -.
DR   OMA; FILRANH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:Ensembl.
DR   GO; GO:0007588; P:excretion; IEA:Ensembl.
DR   GO; GO:0001503; P:ossification; IEA:Ensembl.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    403    427       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    596       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    639    657       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    770    795       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   839 AA;  96271 MW;  5F20230C0677928A CRC64;
     MASVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NVNVNSFQRK FVNEVRRCES
     LERILRFLED EMQNEVVIQL PEKNPLTPLP REMIALETVL EKLEGELQEA NQNQQALKKS
     FLELTELKYL LKKTQDFFET ETNLADDFFI EDTSGLLELR TVPTYMTGKL GFTAGVINRE
     RMASFERLLW RVCRGNIYLK FSEMDTHLED PVTKEEIKKN IFIIFYQGEQ LRKKIKKICD
     GFRATIYPCP EPAAERREML AGVNMRLEDL ITVITQTESH RQCLLQEAAA NWHSWVIKVQ
     KMKAVYHVLN MCNIDVTQQC IIAEIWFPLA DAGRIKKALE QGMELSGSSM VPIMTAVQSK
     TAPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT FPFLFAVMFG DCGHGIVMFL
     AALWMVLSER HLLSQKSDNE IWNTFFHGRY LILLMGIFSI YTGLIYNDCF SKSLNIFGSS
     WSVQPMFRNG TWNTHVMETN SFLQLDPAMP GVYSGNPYPF GIDPIWNLAS NKLTFLNSYK
     MKMSVILGIV QMVFGVILSL FNHIYFRKTV NIILQFIPEM IFILCLFGYL VFMIIFKWCL
     FDVHGSRHAP SILIHFINMF LFNYNDSSNA PLYGHQQEVQ SFFVVMALLS VPWMLLIKPF
     ILRANHRKSQ DLGRLTFQGT SGDSGPPPSH LLGHSEITLH FHDNEQKRKD RKFNFGDVFV
     HQAIHTIEYC LGCISNTASY LRLWALSLAH AQLSEVLWTM VMNIGLRMQG WGGIIGVFII
     FAVFATLTVA ILLIMEGLSA FLHALRLHWV EFQNKFYVGA GYKFAPFSFK HILDGTAEE
//
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