ID H0XIJ6_OTOGA Unreviewed; 831 AA.
AC H0XIJ6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=TCIRG1 {ECO:0000313|Ensembl:ENSOGAP00000015936.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015936.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000015936.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; AAQR03144671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03144672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003798437.1; XM_003798389.2.
DR AlphaFoldDB; H0XIJ6; -.
DR STRING; 30611.ENSOGAP00000015936; -.
DR Ensembl; ENSOGAT00000025350.1; ENSOGAP00000015936.1; ENSOGAG00000028104.1.
DR GeneID; 100965025; -.
DR KEGG; oga:100965025; -.
DR CTD; 10312; -.
DR eggNOG; KOG2189; Eukaryota.
DR GeneTree; ENSGT00950000182881; -.
DR HOGENOM; CLU_005230_0_0_1; -.
DR InParanoid; H0XIJ6; -.
DR OMA; HYVIHTI; -.
DR OrthoDB; 1967517at2759; -.
DR TreeFam; TF300346; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:Ensembl.
DR GO; GO:0030667; C:secretory granule membrane; IEA:Ensembl.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0000045; P:autophagosome assembly; IEA:Ensembl.
DR GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR GO; GO:0045453; P:bone resorption; IEA:Ensembl.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
DR GO; GO:0097188; P:dentin mineralization; IEA:Ensembl.
DR GO; GO:0070166; P:enamel mineralization; IEA:Ensembl.
DR GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
DR GO; GO:0051650; P:establishment of vesicle localization; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0035709; P:memory T cell activation; IEA:Ensembl.
DR GO; GO:0021554; P:optic nerve development; IEA:Ensembl.
DR GO; GO:0001503; P:ossification; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0002158; P:osteoclast proliferation; IEA:Ensembl.
DR GO; GO:0045851; P:pH reduction; IEA:Ensembl.
DR GO; GO:0090383; P:phagosome acidification; IEA:Ensembl.
DR GO; GO:0007039; P:protein catabolic process in the vacuole; IEA:Ensembl.
DR GO; GO:0033365; P:protein localization to organelle; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR GO; GO:0045667; P:regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0010155; P:regulation of proton transport; IEA:Ensembl.
DR GO; GO:0010272; P:response to silver ion; IEA:Ensembl.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR GO; GO:0031529; P:ruffle organization; IEA:Ensembl.
DR GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR GO; GO:0035711; P:T-helper 1 cell activation; IEA:Ensembl.
DR GO; GO:0044691; P:tooth eruption; IEA:Ensembl.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF21; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..831
FT /note="V-type proton ATPase subunit a"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003546035"
FT TRANSMEM 398..422
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 539..558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 597..616
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 767..792
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 136..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 247..277
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 831 AA; 93044 MW; 450BA180EE4FA99F CRC64;
MGSMFRSEEV VLVQLFLPTA AAYTCVSQLG ELGLAEFRDL NASVSAFQRR FVVDVRRCEE
LEKTFTFLQE EVRRAGLVLP APEGRLLAPP PRDLLRIQEE TDRLAQELRD VRGNQQALRT
QLHQLQLHSA VLGQGHGPPL AVTHTDGPLE RTPLLQSPGG PHEDLRVNFV AGAVEPHKAA
ALERLLWRAC RGFLISSFRE TEQQLEDPVT GEPVTWMTFL ISYWGEQIGQ KIRKITDCFH
CHVFPFLEQE EARLRALQQL QQESQELQEV LGETERFLSQ VLGRVQQLLP PRQVQVRKMK
AVYLVLNQCS VSTTHKCLIA EAWCATRDLP TLQEALLDSS SEAGVSAVAH RIPCRDMPPT
LIRTNRFTAS FQGIVDAYGV GRYQEVNPAP YTIITFPFLF AVMFGDVGHG LLMFLFALAM
VLSENQPAVK AAQNEIWQTF FGGRYLLLLM GLFSIYTGFI YNECFSRATA IFPSGWSVAT
MANQSGWSDS FLAQHEVLTL DPNITGVFLG PYPFGIDPVW SLASNHLSFL NSFKMKMSVI
LGVTHMAFGV VLGVFNHMHF GQRHRLLLET LPELIFLLGL FGYLVFLVVY KWLKVSAASA
ASAPSILIHF INMFLFSGSP TNQPLFPGQE VVQSTLVVLA LATVPVLLLG TPLHLLRRQR
HHRSRRSPHG RQEEDKAGLL DSPDMSVNGW GSDEEKAGYL EDEEEAELVP SEVFMHQAIH
TIEFCLGCIS NTASYLRLWA LSLAHAQLSE VLWSMVMHVA LVMSRDVGVA AVVLVPIFAA
FAVMTVAILL VMEGLSAFLH ALRLHWVEFQ NKFYLGTGYK LSPFTFEVED E
//
