ID H0XKW4_OTOGA Unreviewed; 999 AA.
AC H0XKW4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Ankyrin repeat domain 35 {ECO:0000313|Ensembl:ENSOGAP00000016754.1};
GN Name=ANKRD35 {ECO:0000313|Ensembl:ENSOGAP00000016754.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016754.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016754.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NF-kappa-B inhibitor family.
CC {ECO:0000256|ARBA:ARBA00038439}.
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DR EMBL; AAQR03105653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XKW4; -.
DR STRING; 30611.ENSOGAP00000016754; -.
DR Ensembl; ENSOGAT00000031858.1; ENSOGAP00000016754.1; ENSOGAG00000025100.1.
DR eggNOG; ENOG502QXWS; Eukaryota.
DR GeneTree; ENSGT00530000063074; -.
DR HOGENOM; CLU_298955_0_0_1; -.
DR InParanoid; H0XKW4; -.
DR OMA; HGANEDC; -.
DR TreeFam; TF331274; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR PANTHER; PTHR46680:SF3; NF-KAPPA-B INHIBITOR CACTUS; 1.
DR Pfam; PF12796; Ank_2; 2.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 53..85
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 86..118
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 119..151
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 152..184
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 185..217
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 262..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 622..684
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 865..955
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 423..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 999 AA; 109888 MW; AF2F9DB8EEB84799 CRC64;
MKRIFSCSSS QVAVERWNRR DQKLLEAVQQ GDVGRVAALA SRKSARPTKL DSNGQSPFHL
AASKGLTECL TILLANGADI NSKNEDGDTA LHLATISCQP QCVKVLLQHG ANEDAVDAEN
RSPLHWAASS GCASSVLLLC DHEAFLDVLD NDGRTPLMIA SLGGHTAICS QLLQRGARVN
VTDKDDKSAL ILACEKGSAE VAELLLAHGA DAGAVDRTGH DALHYALHTK DEALWRLLQQ
ALNRRRRGGQ SLVQCPDFAS KASPLESQVG SPPKSPWRAE PEEDREEEED ANPCSEEWKW
KYEEQQKKVS QLEQELVRKT EECKTQAAAY LGLENQIREQ VRELGLLLCQ EPAAPGRQDS
SLRPGGDGME QGCPLDLLAK CIQELKKQQQ AAAIVNPTLA SKKAEDSAPG ETQYEVHGRS
QPEEQGLFQS PRSETTGKAT GQHLTTNGGQ TLDPDHNEQL PTGQKENPQV PGVETAGIAV
ETVGTAAMNQ LLLQLREELA AVWREKDAAR GAISRPILEG ALGTSRAEAA AAAWEKMEAR
LERVLVRLDR AKTGLQVKPA QESREGAPKA ALGSIKEDEG KEKRSPGVRG EPLGAPGREQ
TPGGGLAKGH LEKEVSALRL SNSNLMEELG ELGRERQRLQ RELQSLSQRL QREFVPKPEA
QVQLQQLQRS VGLLTEELAV EKEATEKLRK RLASQSSSLR GLWDCLPLDL VGKGSEWGTA
AQPLEELQAC IGALVDRHRE AQQVLARLEE ENQQLRGSLA PRGEPGASSK PPAPPQVAAL
EQDLGKLEEE LRVVQATMSG KSQEIGKLKQ LLYQATEEVA ELRAREAASL RQHEKTRGSL
VAQSQAWGQE LKALLEKYNT ACQEMGRLRE VVAEERRRNR DLAAQAAEQE RQAREMRGRS
EQFEKTAELL KEKMEHLIGA CRDKEAKIKE LLKKLEQLSE EVLAVRGENA RLALQLQESQ
KNHEEIIAIY RNHLLNAAQG YVEQDVYNIL LRILSTQEE
//
