ID H0XL92_OTOGA Unreviewed; 172 AA.
AC H0XL92;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 6 {ECO:0000256|ARBA:ARBA00019579, ECO:0000256|PIRNR:PIRNR037609};
DE Short=BLOC-1 subunit 6 {ECO:0000256|PIRNR:PIRNR037609};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016882.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016882.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. In concert with the AP-3
CC complex, the BLOC-1 complex is required to target membrane protein
CC cargos into vesicles assembled at cell bodies for delivery into
CC neurites and nerve terminals. The BLOC-1 complex, in association with
CC SNARE proteins, is also proposed to be involved in neurite extension.
CC May play a role in intracellular vesicle trafficking, particularly in
CC the vesicle-docking and fusion process.
CC {ECO:0000256|PIRNR:PIRNR037609}.
CC -!- SIMILARITY: Belongs to the BLOC1S6 family.
CC {ECO:0000256|ARBA:ARBA00005767, ECO:0000256|PIRNR:PIRNR037609}.
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DR EMBL; AAQR03104547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XL92; -.
DR STRING; 30611.ENSOGAP00000016882; -.
DR Ensembl; ENSOGAT00000034249.1; ENSOGAP00000016882.1; ENSOGAG00000032835.1.
DR eggNOG; ENOG502RZNC; Eukaryota.
DR GeneTree; ENSGT00510000047812; -.
DR HOGENOM; CLU_115118_1_0_1; -.
DR InParanoid; H0XL92; -.
DR OMA; MMSDVKR; -.
DR TreeFam; TF325188; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR017242; BLOC-1_pallidin.
DR InterPro; IPR028119; Snapin/Pallidin/Snn1.
DR PANTHER; PTHR31328; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6; 1.
DR PANTHER; PTHR31328:SF2; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6; 1.
DR Pfam; PF14712; Snapin_Pallidin; 1.
DR PIRSF; PIRSF037609; BLOC-1_complex_pallidin; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 172 AA; 19791 MW; 2835A4D1D72C8F09 CRC64;
HECPWAAVPE WAPTGPPNSL EAGEPTPGLS DTSPDEGLIE DLPVEDKAVE QLAEGLLSHY
LPDLQRSKQA LQELTQNQVV LLDTLEQEIS KFKECHSMLD INALFTEAKH YHAKLVNIRK
EMLMLHEKTS KVKKRALQLQ QKRQKEELER EQQREKELER EKQLTARPAK RT
//
