ID H0XLY6_OTOGA Unreviewed; 392 AA.
AC H0XLY6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 08-NOV-2023, entry version 57.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000017126.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000017126.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AAQR03180327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XLY6; -.
DR STRING; 30611.ENSOGAP00000017126; -.
DR Ensembl; ENSOGAT00000024590.1; ENSOGAP00000017126.1; ENSOGAG00000026406.1.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000153747; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR InParanoid; H0XLY6; -.
DR OMA; CGFKHYV; -.
DR TreeFam; TF314990; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 74..389
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT DISULFID 105..110
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 272..276
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 392 AA; 43900 MW; 3281121E29E57D0A CRC64;
HHQDLLLIYG RRITFATSLV PLMKVKSMRE NLQENGMLKE YLEKYPYSQA KVLSEDKDKK
VTYESLRNYL DLAYVGLISI GTPPQKFRVA FDTGSADLWV PSIYCNSQSC GSHAFFNPQM
SSTLQLPPGL IRRAQIRYSY GDVLGILALD TLKIGDLEAF NQIFVLSTWE GHSFGSFAPF
DGILGLAYPD SAQTVATPVF DNLWEQSLIS ENLFAFYLTS RETGGKRGSM LMLGGVDHSY
YSGELRWVPV TRQRFWQVAL NRITVNGTII ACHDGCQAIL NTGSSVVNGP YEDVLNIQNI
IHAQHSFNDM YMDCNTTTNL PDVVFVIGGI NYPVPARSYV RKDAYGTCVS TFESLAVNPF
GSEMWILGDV FLRLYFSVYD RANNRVGLAP AI
//