GenomeNet

Database: UniProt
Entry: H0XM18_OTOGA
LinkDB: H0XM18_OTOGA
Original site: H0XM18_OTOGA 
ID   H0XM18_OTOGA            Unreviewed;       391 AA.
AC   H0XM18;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   08-NOV-2023, entry version 60.
DE   RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000017158.1, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000017158.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   EMBL; AAQR03191344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03191345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03191346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0XM18; -.
DR   STRING; 30611.ENSOGAP00000017158; -.
DR   Ensembl; ENSOGAT00000029174.1; ENSOGAP00000017158.1; ENSOGAG00000029061.1.
DR   eggNOG; KOG1339; Eukaryota.
DR   GeneTree; ENSGT00940000153747; -.
DR   InParanoid; H0XM18; -.
DR   OMA; NESETWI; -.
DR   TreeFam; TF314990; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.60; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..391
FT                   /note="Peptidase A1 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012497502"
FT   DOMAIN          73..388
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        91
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        277
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        104..109
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        268..272
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        311..347
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   391 AA;  43739 MW;  D7337C311B794DB1 CRC64;
     MKWLVVLGLV ALSECLVRVP LMKVKSMREN LQENGMLKEY LEKYPNSPVK FLSNDQNKKV
     TYESLSNYLD MVYVGLITIG TPPQTFKVVF DTGSADLWVP SVFCKTPSCD THQRFNPWRS
     STFKLPPGPV RPLKLRYGSG DILGVVAQDT LKIGNLEDVD QTFVLSTWED QAFGAFAPFD
     GILGLGYPDA VQAGGTPVFD NIWKKGLITA NLFAFYFTSE RKTGSMLMLG GVNDSYYSGE
     LRWVPVTKQR YWQVALDSIT VNGIVIACHD GCQAILDTGS SVVNGPYEDV LNIQNIIHAQ
     HTFTDMYIID CTNTTHLPDV VFVIGGINYP VPARSYIRKD EDAFDTCLST FRSFPDNTFN
     SKTWILGDVF LRVYFSVYDR ANNRVGLAPA I
//
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