ID H0XM18_OTOGA Unreviewed; 391 AA.
AC H0XM18;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 08-NOV-2023, entry version 60.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000017158.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000017158.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AAQR03191344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03191345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03191346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XM18; -.
DR STRING; 30611.ENSOGAP00000017158; -.
DR Ensembl; ENSOGAT00000029174.1; ENSOGAP00000017158.1; ENSOGAG00000029061.1.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000153747; -.
DR InParanoid; H0XM18; -.
DR OMA; NESETWI; -.
DR TreeFam; TF314990; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..391
FT /note="Peptidase A1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012497502"
FT DOMAIN 73..388
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 91
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 277
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 104..109
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 268..272
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 311..347
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 391 AA; 43739 MW; D7337C311B794DB1 CRC64;
MKWLVVLGLV ALSECLVRVP LMKVKSMREN LQENGMLKEY LEKYPNSPVK FLSNDQNKKV
TYESLSNYLD MVYVGLITIG TPPQTFKVVF DTGSADLWVP SVFCKTPSCD THQRFNPWRS
STFKLPPGPV RPLKLRYGSG DILGVVAQDT LKIGNLEDVD QTFVLSTWED QAFGAFAPFD
GILGLGYPDA VQAGGTPVFD NIWKKGLITA NLFAFYFTSE RKTGSMLMLG GVNDSYYSGE
LRWVPVTKQR YWQVALDSIT VNGIVIACHD GCQAILDTGS SVVNGPYEDV LNIQNIIHAQ
HTFTDMYIID CTNTTHLPDV VFVIGGINYP VPARSYIRKD EDAFDTCLST FRSFPDNTFN
SKTWILGDVF LRVYFSVYDR ANNRVGLAPA I
//