ID H0XMH5_OTOGA Unreviewed; 534 AA.
AC H0XMH5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Syntrophin beta 1 {ECO:0000313|Ensembl:ENSOGAP00000017316.1};
GN Name=SNTB1 {ECO:0000313|Ensembl:ENSOGAP00000017316.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000017316.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000017316.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the syntrophin family.
CC {ECO:0000256|ARBA:ARBA00010798}.
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DR EMBL; AAQR03010493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03010494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03010495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03010496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XMH5; -.
DR STRING; 30611.ENSOGAP00000017316; -.
DR Ensembl; ENSOGAT00000027912.1; ENSOGAP00000017316.1; ENSOGAG00000034441.1.
DR eggNOG; KOG3551; Eukaryota.
DR GeneTree; ENSGT00950000182863; -.
DR HOGENOM; CLU_026406_3_1_1; -.
DR InParanoid; H0XMH5; -.
DR OMA; RAETCKD; -.
DR TreeFam; TF317932; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00821; PH; 1.
DR CDD; cd01258; PHsplit_syntrophin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR041428; PHsplit_syntrophin.
DR InterPro; IPR015482; Syntrophin.
DR PANTHER; PTHR10554:SF11; BETA-1-SYNTROPHIN; 1.
DR PANTHER; PTHR10554; SYNTROPHIN; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF18012; PH_17; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 15..294
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 108..191
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 318..429
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 201..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 57678 MW; DA35871593D97C32 CRC64;
AGKMAVAAAG GGGGRAQRSG LLEVLVRDRW HKVLVNLSED ALVLSCEEGA AAYNGIGTAT
NGSFCRGTGA GHPGAGSAQP PDSPAGVRTA FTDLPEQVPE SISNQKRGVK VLKQELGGLG
ISIKGGKENK MPILISKIFK GLAADQTQAL YVGDAILSVN GADLRDATHD EAVQALKRAG
KEVLLEVKYM REATPYVKKG SPVSEIGWET PPPESPRLGG SSADPLSSQS FSFHRDRKSI
PLKMCYVTRS MALADPENRQ LEIHSPDAKH TVILRSKDSA TAQAWFSAIH ANVSELVTRV
IAEVREQLGK AGVAGSREIR HLGWLAEKVP GDSEKQWKPA LVVLTEKDLL IYDSMPRRKE
AWASPVHTYP LLATRLVHSG PGKGSPQAGV DLSFATRTGT RQGIETHLFR AETSRELSHW
TRSVVQGCHN AAELITEITA ACTYKNQECR LTIHYENGFS ITTEPQEGAF PKTILQSPYE
KLKMSSDDGI RMLYLDFGGK DGEIQLDLHS CPKPIVFIIH SFLSAKITRL GLVA
//