ID H0XQ10_OTOGA Unreviewed; 545 AA.
AC H0XQ10;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Debranching RNA lariats 1 {ECO:0000313|Ensembl:ENSOGAP00000018201.1};
GN Name=DBR1 {ECO:0000313|Ensembl:ENSOGAP00000018201.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018201.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018201.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the lariat debranching enzyme family.
CC {ECO:0000256|ARBA:ARBA00006045}.
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DR EMBL; AAQR03062415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003789471.1; XM_003789423.2.
DR AlphaFoldDB; H0XQ10; -.
DR STRING; 30611.ENSOGAP00000018201; -.
DR Ensembl; ENSOGAT00000027194.1; ENSOGAP00000018201.1; ENSOGAG00000033095.1.
DR GeneID; 100965820; -.
DR KEGG; oga:100965820; -.
DR CTD; 51163; -.
DR eggNOG; KOG2863; Eukaryota.
DR GeneTree; ENSGT00510000047481; -.
DR HOGENOM; CLU_005893_0_2_1; -.
DR InParanoid; H0XQ10; -.
DR OMA; GIDDPLC; -.
DR OrthoDB; 1220605at2759; -.
DR TreeFam; TF313221; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008419; F:RNA lariat debranching enzyme activity; IEA:Ensembl.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR CDD; cd00844; MPP_Dbr1_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR007708; DBR1_C.
DR InterPro; IPR041816; Dbr1_N.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR12849:SF0; LARIAT DEBRANCHING ENZYME; 1.
DR PANTHER; PTHR12849; RNA LARIAT DEBRANCHING ENZYME; 1.
DR Pfam; PF05011; DBR1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SMART; SM01124; DBR1; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 235..380
FT /note="Lariat debranching enzyme C-terminal"
FT /evidence="ECO:0000259|SMART:SM01124"
FT REGION 394..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 61819 MW; D8C42AFD7DA78672 CRC64;
MRVAVAGCCH GELDKIYETL ALAERRGPGR VDLLLCCGDF QAVRNEADLR CMAVPPKYRH
MQTFYRYYSG EKKAPVLTIF IGGNHEASNH LQELPYGGWV APNIYYLGLA GVVKYRGVRI
GGISGIFKSH DYRKGHFECP PYNSSTIRSI YHVRNIEVYK LKQLKQPIDI FLSHDWPRSI
YHYGNKKQLL KTKSFFRQEV ENNTLGSPAA SELLEHLKPT YWFSAHLHVK FAALMQHQAK
DKEQTAKATK FLALDKCLPH RDFLQVLEIK HDPSAPDYLE YDIEWLTILS ATDDLINVTG
HLWNMPENNG LHARWDYSAT EEAMKEVLEK LNHDLKVPCN FSITAACYDP SKPQTQMQLV
HRLNPQTTEF CAQLGITDLN VRLQKAKEEH QFCGEYEEQD GVESNDSGED RSEYNTDTSA
LSSINPDEIM LDEEEEDEDS IVSAHSDVNT PSVEPSDRAS DFSTSFSDVR ILPSSMMVSS
DDTLGSPVVT EGKCDEAVES GDGEDLTKVP LKRLSDEHEP EQRKKIKRRN QAIYAAVDDD
DDYAA
//
