ID H0XQV8_OTOGA Unreviewed; 607 AA.
AC H0XQV8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Serine/threonine-protein kinase PLK {ECO:0000256|RuleBase:RU361162};
DE EC=2.7.11.21 {ECO:0000256|RuleBase:RU361162};
DE AltName: Full=Polo-like kinase {ECO:0000256|RuleBase:RU361162};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018500.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018500.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.21; Evidence={ECO:0000256|RuleBase:RU361162};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. CDC5/Polo subfamily. {ECO:0000256|RuleBase:RU361162}.
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DR EMBL; AAQR03058689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XQV8; -.
DR STRING; 30611.ENSOGAP00000018500; -.
DR Ensembl; ENSOGAT00000024090.1; ENSOGAP00000018500.1; ENSOGAG00000027767.1.
DR eggNOG; KOG0575; Eukaryota.
DR GeneTree; ENSGT00940000162321; -.
DR HOGENOM; CLU_000288_46_1_1; -.
DR InParanoid; H0XQV8; -.
DR OMA; GCIMYMV; -.
DR TreeFam; TF101089; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13118; POLO_box_1; 1.
DR CDD; cd14099; STKc_PLK; 1.
DR Gene3D; 3.30.1120.30; POLO box domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033701; POLO_box_1.
DR InterPro; IPR000959; POLO_box_dom.
DR InterPro; IPR036947; POLO_box_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24345:SF43; INACTIVE SERINE_THREONINE-PROTEIN KINASE PLK5; 1.
DR PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00659; POLO_box; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF82615; Polo-box domain; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50078; POLO_BOX; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|RuleBase:RU361162};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU361162};
KW Transferase {ECO:0000256|RuleBase:RU361162}.
FT DOMAIN 14..266
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 437..500
FT /note="POLO box"
FT /evidence="ECO:0000259|PROSITE:PS50078"
FT BINDING 43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 607 AA; 67356 MW; 62EC98AD86103AFC CRC64;
VAAFLRDPSS GRVYRRGKLI GKGAFSHCYK LTDMSTSAVF ALKVVPRRGA GHLCPGGKVE
REITLHSCLR HRNIVAFHGH FADRDHVYMV LEYCSRQSLA HVLKARHTLT EPEVRYYLRG
LVSGLRYLHQ RHIVHRDLKP SNFFLNKNME VKIGDLGLAA RVGPGGHCHR VLCGTPNFQA
PEVISRNGHS CQSDIWALGC IMYMVLTGTP PFMAAPLSEM YQNIRDGHYP EPAHLSPNAR
HLIARLLAPN PGERPSLDHL LEDDFFTQGF TPDRLPPHSC HSPPIFTIPL PLGRLFQKAG
QLLLSQCRPP CEYITHYPCP HPQRYISRGK QFLCVLSLPR QRAGHRGVLE ERPPLTSAAP
CSGLPVQEVS QPLGYGVRIQ NLAANESVST EPEGSQKLEV EVAIRNLQLC LDAGPSAIRN
PPGEQQPVIW ALKWVDYSSK YGFGYQLSDG SSGVLLRDGT HMALRSPGGQ VCYMPDRGKL
ETFTLRDVPR LLGTKLAVLR LFACHMQQQL RKEGAPPMPT LPARPSLCLL RFLASKQALL
LLFNNGTVQV SLTGVQAHLV LSGEGEELLL THWEQGHPGT SYSLGILRSH GCTLATRQLL
HHALCML
//
