ID H0XTL5_OTOGA Unreviewed; 1431 AA.
AC H0XTL5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=CASK interacting protein 1 {ECO:0000313|Ensembl:ENSOGAP00000019457.1};
GN Name=CASKIN1 {ECO:0000313|Ensembl:ENSOGAP00000019457.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000019457.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000019457.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AAQR03078027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003790846.1; XM_003790798.1.
DR STRING; 30611.ENSOGAP00000019457; -.
DR Ensembl; ENSOGAT00000026546.1; ENSOGAP00000019457.1; ENSOGAG00000034517.1.
DR GeneID; 100958494; -.
DR KEGG; oga:100958494; -.
DR CTD; 57524; -.
DR eggNOG; KOG0507; Eukaryota.
DR GeneTree; ENSGT00940000158025; -.
DR HOGENOM; CLU_003619_1_1_1; -.
DR InParanoid; H0XTL5; -.
DR OMA; LFCLHGQ; -.
DR OrthoDB; 25046at2759; -.
DR TreeFam; TF320582; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12062; SH3_Caskin1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035495; Caskin1_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF11; CASKIN-1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 114..146
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 147..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 188..220
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 220..252
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 281..347
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 474..537
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 543..607
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 348..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1017..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1342
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1431 AA; 150151 MW; 0526E44BC892F57F CRC64;
MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDSDGF SALHHAALNG
NTELITLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL VLKAGSAVNI PSDEGHIPLH
LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT PLDLACEFGR VGVVQLLLSS NMCATLLEPR
PGDATDPNGT SPLHLAAKNG HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL
LDSGINAHVR NTYSQTALDI VHQFTTSQAS KEIKQLLREA SAALQVRATK DYCNNYDLTS
LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG SRAGTEPSPS
QGGGPLGPSA PPEEIWVLRK PFAGGDRSSS SSVSSVAGGR GSGGHALHAG SEGVKLLATV
LSQKSVSESS PGDSPAKPPE GSTGAARSQP TVAHAGQVYG DQPPKKLEPA SEGKSAEAVS
QWLATFQLQL YTPNFVNSGY DLPTISRMTP EDLTAIGVTK PGHRKKITAE ISGLSVPDWL
PEHKPANLAV WLSMIGLAQY YKVLVENGYE NIDFITDITW EDLQEIGITK LGHQKKLMLA
VRKLAELQKA EYAKYEGGPL RRKAPQSLEV LAIESPPPPE PAPTDCQSPK MTTFQDSELS
GELQAAMTGP AEGVTAAPSE KPSNHLPATP RATMRQEPSL GGRARHMSSS QELLGDGPPG
PGSPMSRSQE YLLDEGPAPG TPLKEARPSR HGHSVKRASV PPVPGKPRQA LPPGASHFTP
PQTPTKARPG SPQALGVPHG PAPATAKVKP TPQLLPPTER PMSPRSLPQS PTHRGFAYVL
PQPVEGEVGP TALGPAPPLV PAAVPTLCLP PEADTEPGRP KKRAHSLNRY AASDSEPERD
ELLVPAAAGP YATVQRRVGR SHSVKVPAGT DKNVNRSQSF AVRPRKKGPP PPPPKRSSSA
MASANLADEQ VPDAEAEDGL LGVRAQRRRA SDLAGSVDTG SAGSVKSIAA MLELSSIGGG
GRAARRPPEG HPTPQPASPE PGRVATVLAS VKHKEAIGPD GEVVNRRRTL SGPVTGLLAT
ARRGPEESAD QGHFVENGAG RPRPRGPVKG EANVEGPPLA RVEASATLKR RIRAKQSQQE
NVKFILTESD TVKRRPKAKE REAGPEPPPS LSVYQNGMGI ARRLPASDQA GPPELPPPPP
PAEPPPADLV HLPPLPPLES DARKLAKPPV SPKPVLAQPV PKIQGSPTPT SKKVPLPGPG
SPEVKRAHGT PPPVSPKPPP PPTAPKPAKV VAGLPPGSAS PSPAPSPARQ PPAALAKPPS
TPPSLSASPA KPPSPGAPAL HVPTKPPRAA AAAAGAPAAP DGASPGDSAR QKLEETSACL
AAALQAVEEK IRQEDGQGPR PLAAEKSTGS ILDDIGSMFD DLADQLDAML E
//
