ID H0XU27_OTOGA Unreviewed; 545 AA.
AC H0XU27;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Homeobox and leucine zipper encoding {ECO:0000313|Ensembl:ENSOGAP00000019619.1};
GN Name=HOMEZ {ECO:0000313|Ensembl:ENSOGAP00000019619.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000019619.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000019619.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; AAQR03175795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003801975.1; XM_003801927.2.
DR AlphaFoldDB; H0XU27; -.
DR STRING; 30611.ENSOGAP00000019619; -.
DR Ensembl; ENSOGAT00000033486.1; ENSOGAP00000019619.1; ENSOGAG00000032616.1.
DR GeneID; 100963058; -.
DR KEGG; oga:100963058; -.
DR CTD; 57594; -.
DR eggNOG; KOG3986; Eukaryota.
DR GeneTree; ENSGT00950000182893; -.
DR HOGENOM; CLU_032878_0_0_1; -.
DR InParanoid; H0XU27; -.
DR OMA; RYWATHQ; -.
DR OrthoDB; 4218493at2759; -.
DR TreeFam; TF333363; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR PANTHER; PTHR15467:SF7; HOMEOBOX AND LEUCINE ZIPPER PROTEIN HOMEZ; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF11569; Homez; 1.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 352..412
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 354..413
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 61348 MW; 6265A56A5B70B375 CRC64;
MVRGWEPPPG PDRAISEGHK SESIMPPNKE ASSLNSSPAG LICLPPISEE LQLVWTQAAQ
TSELDGNEHL LQTFSYFPYP SLADIALLCL RYGLQMEKVK TWFMAQRLRC GISWSSEEIE
ETRARVVYHR DQLHFKSLLS FTHHAGRPPE DVPPSPMPSQ EQVGLGIGPL TLSDPTQMKG
LKVEPEDSSQ RPPLPLSHQK AKDPQMTVGS RTFPQQSDLW QDHQRSGLSK ELAGRGPEQS
HGMDTASWNH SKAVHQPCAR DKPTAISLLT SSCKESASTM TPSSSTSSSF QVLANGAAAT
SKPLQPQGCI PQSLSPKEQA LPPHLEPAWP QRLRHNSVPG RVGPAEYLSP DTQRQRKTKR
KTKEQLAILK SFFLQCQWAR REDYHKLEQI TGLPRPEIIQ WFGDTRYALK HGQLKWFRDN
TVPGVPSFQD SAVPTSSPST RSLNEWAETP PLPIPPPPPD IRPLERYWAA HQRLRESDIP
QLSKASRLST QQVLDWFDSR LPEPAEVVVC LDEEEEEEEE ELPEDDEEEE EEEEEEDDDD
VIIQE
//
