ID H0XV07_OTOGA Unreviewed; 338 AA.
AC H0XV07;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Nuclear apoptosis-inducing factor 1 {ECO:0000256|ARBA:ARBA00014166};
GN Name=NAIF1 {ECO:0000313|Ensembl:ENSOGAP00000019949.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000019949.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000019949.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Induces apoptosis. {ECO:0000256|ARBA:ARBA00003564}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NAIF1 family.
CC {ECO:0000256|ARBA:ARBA00010629}.
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DR EMBL; AAQR03035899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XV07; -.
DR STRING; 30611.ENSOGAP00000019949; -.
DR Ensembl; ENSOGAT00000024133.1; ENSOGAP00000019949.1; ENSOGAG00000031498.1.
DR eggNOG; ENOG502QW9U; Eukaryota.
DR GeneTree; ENSGT00450000040324; -.
DR HOGENOM; CLU_078961_0_0_1; -.
DR InParanoid; H0XV07; -.
DR OMA; QQDGMIQ; -.
DR TreeFam; TF332812; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; IEA:Ensembl.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR PANTHER; PTHR23098; AGAP001331-PA-RELATED; 1.
DR PANTHER; PTHR23098:SF7; NUCLEAR APOPTOSIS-INDUCING FACTOR 1; 1.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 12..89
FT /note="Myb/SANT-like DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF13873"
FT REGION 91..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 36827 MW; 3A0B7D07FA7600BC CRC64;
RGGAMAVPAK KRKMNFSERE VEIIVEELEL KKHLLVNHFN AGVPLAAKSA AWHSILRRVN
AVATCRRELP EVKKKWSDLK TEVRRKVAQV RAAVEGGEAP GPTEEDGAGG PGTGGGSGGG
GPAVAPVLLT PMQQRICNLL GEATIISLPS TTVGQHGQRE RETFTEHFSW CCPTSFSAWP
EVPTETAYHT LEEGVVEYCT TEAPPPLPAE APVEMMAQHA DTSVKPQALK SRIALNSAKL
IQEQRVTNLH VKEIAQHLEQ QNDLLQMIRR SQEVQACAQE RQAQAMEGTQ AALSVLIQVL
RPMIKDFRRY LQSNTPNPAP ASDPGQVAQN GQPDSIIQ
//