ID H0XYN6_OTOGA Unreviewed; 387 AA.
AC H0XYN6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021229.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000021229.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; AAQR03189706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03189707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XYN6; -.
DR STRING; 30611.ENSOGAP00000021229; -.
DR Ensembl; ENSOGAT00000027140.1; ENSOGAP00000021229.1; ENSOGAG00000029662.1.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000153747; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR InParanoid; H0XYN6; -.
DR OMA; RRECTAM; -.
DR TreeFam; TF314990; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 56..384
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 74
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 272
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 87..92
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 263..267
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 387 AA; 43584 MW; C3213040CFBB85E5 CRC64;
RVPLMKVKSM RENLQENGML KEYLEKYPYS PVKFLSNDQN KKVNYGYLRN YLDLVYVGLI
TIGTPPQTFR VVFDTGCADF WLPSVFCYTQ SCNTHERFDP QSSSTFNFPS GELRTVKLSY
GSGEIVGVIA YDTLKEHPFL PQIGDLEDIN QAFVLSTSVD QAFGSFVEFD GILGLAYPEL
AQVRRTPVFD KLWKKGRISE NLFAFYLTRK KKNAGGKRGS MLMLGGVDHS YYSGELRWVP
VTKQRYWQVA LDSITVNGTI IACHDGCQAI LDTGCSVVDG PNEDVLQIQN IIHAQPSFNN
MYVIDCNTTT QLPDVVFVIG GINYPVPARS YIRKFLQEAF GTCVSAFESF PDNTFGSKTW
ILGDLFLSLY FSIYDRANNR VGLAPAI
//