ID H0Y0R9_OTOGA Unreviewed; 421 AA.
AC H0Y0R9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Zinc transporter ZIP13 {ECO:0000256|ARBA:ARBA00040592};
DE AltName: Full=Solute carrier family 39 member 13 {ECO:0000256|ARBA:ARBA00042542};
DE AltName: Full=Zrt- and Irt-like protein 13 {ECO:0000256|ARBA:ARBA00042972};
GN Name=SLC39A13 {ECO:0000313|Ensembl:ENSOGAP00000021962.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021962.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000021962.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; AAQR03002901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03002902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0Y0R9; -.
DR STRING; 30611.ENSOGAP00000021962; -.
DR Ensembl; ENSOGAT00000030241.1; ENSOGAP00000021962.1; ENSOGAG00000012440.2.
DR eggNOG; KOG2694; Eukaryota.
DR GeneTree; ENSGT00940000157349; -.
DR InParanoid; H0Y0R9; -.
DR OMA; TGDSVHC; -.
DR TreeFam; TF318470; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0061448; P:connective tissue development; IEA:Ensembl.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:Ensembl.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR16950; ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4; 1.
DR PANTHER; PTHR16950:SF16; ZINC TRANSPORTER ZIP13; 1.
DR Pfam; PF02535; Zip; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..421
FT /note="Zinc transporter ZIP13"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003546279"
FT TRANSMEM 68..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 421 AA; 44247 MW; 0D8A813441606006 CRC64;
MPGCPCPGCG MAGQRLLFLT ALALELLGMA GGSQPALRSW GAAAACRLDN KESDSWGALL
SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTMLRSE AGARRLKQLL SFALGGLLGN
VFLHLLPEAW AYTCSASPGG EGQSLQQQQQ LGLWVIAGIL SFLALEKMFL DNKERQGTTQ
APSKDPTTAA ATLNGGRCLA QPVAEPGLSV VVRSIKVRGY LNLLANTIDN FTHGLAVAAS
FLVSKKIGFL TTMAILLHEI PHEVGDFAIL LRAGFDRWSA AKLQLSTALG GLLGACFAIC
TQSPKGVGTG MRVVVSSGVL AKCGMSALLL VSRPGSDLVS PVGGGRTHGP LGSKPVGHSP
LTTEETVAWI LPFTSGGFLY IALVNVLPDL LEEDDPWHSL QQVILLCTGI MVMVLFSLFV
E
//
