GenomeNet

Database: UniProt
Entry: H0Y0T2_OTOGA
LinkDB: H0Y0T2_OTOGA
Original site: H0Y0T2_OTOGA 
ID   H0Y0T2_OTOGA            Unreviewed;      5022 AA.
AC   H0Y0T2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   22-NOV-2017, entry version 43.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSOGAP00000021975};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSOGAP00000021975};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021975, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000021975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000021975}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000021975}.
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DR   EMBL; AAQR03125439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000021975; -.
DR   Ensembl; ENSOGAT00000029811; ENSOGAP00000021975; ENSOGAG00000028400.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H0Y0T2; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4308   4325       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4545   4565       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4633   4656       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4762   4782       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4822   4844       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4903   4926       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       82    137       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      144    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      195    249       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      255    318       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      320    377       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      566    782       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      998   1193       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1342   1555       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1854   1907       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5022 AA;  563819 MW;  459B0AC92C5D1CA5 CRC64;
     DDEVVLQCSA TVLKEQLKLC LAAEGFGNRL CFLEPTSNAQ NVPPDLAICC FVLEQSLSVR
     ALQEMLANTV EAGVESSQGG GHRTLLYGHA ILLRHAHSRM YLSCLTTSRS MTDKLAFDVG
     LQEDATGEAC WWTMHPASKQ RSEGEKVRVG DDIILVSVSS ERYLHLSTAS GELQVDASFM
     QTLWNMNPIC SRCEEGYVTG GHVLRLFHGH MDECLTISPA DSDDQRRLVF YEGGAVCTHA
     RSLWRLEPLR ISWSGSHLRW GQPLRIRHVT TGRYLALTED QGLVVVDASK AHTKATSFCF
     RISKEKLDTA PKRDVEGMGP PEIKYGESLC FVQHVASGLW LTYAAPDPKA LRLGVLKKKA
     MLHQEGHMDD ALSLTRCQQE ESQAARMIYS NAGLYNQFIK GLDSFSGKPR GSGPPAGTAL
     PIEGVILSLQ DLIVYFEPPS EELQHEEKQS KLRSLRNRQS LFQEEGMLSL VLNCIDRLNV
     YTTAAHFAEF AGEEAAESWK EIVNLLYELL ASLIRGNRTN CALFSTNLDW LVSKLDRLEA
     SSGILEVLYC VLIESPEVLN IIQENHIKSI ISLLDKHGRN HKVLDVLCSL CVCNGVAVRS
     NQDLITENLL PGRELLLQTN LINYVTSIRP NIFVGRAEGS TQYNKWYFEV MVDEVVPFLT
     AQATHLRVGW ALTEGYSPYP GGGEGWGGNG VGDDLYSYGF DGLHLWTGHV ARPVTSPGQH
     LLAPEDVVSC CLDLSVPSIS FRINGCPVQG VFEAFNLDGL FFPVVSFSAG VKVRFLLGGR
     HGEFKFLPPP GYAPCHEAVL PRERLHLEPI KEYRREGPRG PHLVGPSRCL SHTDFVPCPV
     DTVQIVLPPH LERIREKLAE NIHELWALTR IEQGWTYGPV RDDNKRLHPC LVNFHSLPEP
     ERNYNLQMSG ETLKTLLALG CHVGMADEKA EDNLKKTKLP KTYMMSNGYK PAPLDLSHVR
     LTPAQTTLVD RLAENGHNVW ARDRVGQGWS YSAVQDIPAR RNPRLVPYRL LDEATKRSNR
     DSLCQAVRTL LGYGYNIEPP DQEPSQVESQ SRWDRVRIFR AEKSYAVQSG RWYFEFEAVT
     TGEMRVGWAR PELRPDVELG ADELAYVFNG HRGQRWHLGS EPFGRPWQSG DVVGCMIDLT
     ENTIIFTLNG EVLMSDSGSE TAFRDIEIGD GFLPVCSLGP GQVGHLNLGQ DVSSLRFFAI
     CGLQEGFEPF AINMQRPVTT WFSKSLPQFE AVPLEHPHYE VARMDGTVDT PPCLRLTHRT
     WGSQNSLVEM IFLRLSLPVQ FHQHFRCTAG ATPLASPGLQ PPAEDEARAA EPDPDYENLR
     RSAGGWGETE GGKEGTAKEG VPGGTPQAGA EAQPARVENE KDATTEKNKK RGFLFKAKKV
     AMMTQPPATP ALPRLPRDVV PADNRDDPEI ILNTTTYYYS VRVFAGQEPS CVWVGWVTPD
     YHQHDMNFDL SKVRAVTVTM GDEHGNVHSS LKCSNCYMVW GGDFVSPGQQ GRISHSDLVI
     GCLVDLATGL MTFTANGKES NTFFQVEPNT KLFPAAFVLP TNQNVIQFEL GKQKNIMPLS
     AAMFLSERKN SAPQCPPRLE MQMLMPVSWS RMPNRFLQVE TRRAGERLGW AVQCQEPLTM
     MALHIPEENR CMDILELSER LQLQRFHSHT LRLYRAVCAL GNNRVAHALC SHVDQAQLLH
     ALEDAHLPGP LRAGYYDLLI SIHLESACRS RRSMLSEYIV PLTEETRTIT LFPSGRSTEN
     GPCHHGLPGV GITTSLRPPH HFSPPCFVAA LQAAGVAEAP VRLSPAIPLE ALRDKALRML
     GEAVRDGGQH ARDPVGGSVE FQFVPVLKLV STLLVMGIFG DEDVKQILKL IEPEVFTEEE
     EEEEEEEEEE DEEEKEADEE EEAQEKEDEE KEEEEEAEGE KEEGLEEGLL QMKLPESVKL
     QMCHLLEYFC DQELQHRVES LAAFAERYVD KLQENQRSRY GLLMKAFTMS AAETARRTRE
     FRSPPQEQIN MLLHFKDPSN EEDCPLSEEL RQDLLDFHQD LLAHCGIQLE GEEEEPEEET
     TLGSRLMSLL EKVRLVKKKE EGPEEEPPAE ESKPRSLQEL VSHTVVRWAQ EDFVQSPELV
     RAMFSLLHRQ YDGLGELLRA LPRAYTISPS SMEDTMSLLE CLGQIRSLLI VQMGPQEENL
     MIQSIGNIMN NKVFYQHPNL MRALGMHETV MQVMVNVLGG GESKEIRFPK MVTSCCRFLC
     YFCRISRQNQ RSMFDHLSYL LENSGIGLGM QGSTPLDVAA ASVIDNNELA LALQEQDLEK
     VVSYLAGCGL QSCPMLLAKG YPDIGWNPCG GERYLDFLRF AVFVNGESVE ENANVVVRLL
     IRKPECFGPA LRGEGGSGLL AAIEEAIRIS EDPARDGPGV RRDRRREHFG EEPPEENRVH
     LGHAIMSFYA ALIDLLGRCA PEMHLIQAGK GEALRIRAIL RSLVPLEDLV GIISLPLQIP
     TLGKDGALVQ PKMSASFVPD HKGSMVLFLD RVYGIENQDF LLHVLDVGFL PDMRAAASLD
     TATFSTTEMA LALNRYLCLA VLPLITKCAP LFAGTEHRAI MVDSMLHTVY RLSRGRSLTK
     AQRDVIEDCL MALCRYIRPS MLQHLLRRLV FDVPILNEFA KMPLKLLTNH YERCWKYYCL
     PTGWANFGVT SEEELHLTRK LFWGIFDSLA HKKYDPELYR MAMPCLCAIA GALPPDYVDA
     SYSSKAEKKA TVDAEGNFDP RPVETLNVII PEKLDSFINK FAEYTHEKWA FDKIQNNWSY
     GENVDEELKT HPMLRPYKTF SEKDKEIYRW PIKESLKAMI AWEWTIEKAR EGEEEKTEKK
     KTRKISQSAQ TYDAREGYNP QPPDLSGVTL SRELQAMAEQ LAENYHNTWG RKKKQELEAK
     GGGTHPLLVP YDTLTAKEKA RDREKAQELM KFLQMNGYAV TRGLKDMELD SSSIEKRFAF
     GFLQQLLRWM DISQEFIAHL EAVVSSGRVE KSPHEQEIKF FAKILLPLIN QYFTNHCLYF
     LSTPAKVLGS GGHASNKEKE MITSLFCKLA ALVRHRVSLF GTDAPAVVNC LHILARSLDA
     RTVMKSGPEI VKAGLRSFFE SASEDIEKMV ENLRLGKVSQ ARTQVKGVGQ NLTYTTVALL
     PVLTTLFQHI AQHQFGDDVI LDDVQVSCYR TLCSIYSLGT TKNAYVEKLR PALGECLARL
     AAAMPVAFLE PQLNEFNACS VYTTKSPRER AILGLPNSVE EMCPDIPVLE RLMADIGGLA
     ESGARYTEMP HVIEITLPML CSYLPRWWER GPEAPPPTAG APPPCTAVTS DHLNSLLGNI
     LRIIVNNLGI DEASWMKRLA VFAQPIVSRA RPELLHSHFI PTIGRLRKRA AKVVAEEEQL
     RLEAKAEAQE GEMLVRDEFS VLCRDLYALY PLLIRYVDNN RAQWLTEPNP NAEELFRMVG
     EIFIYWSKSH NFKREEQNFV VQNEINNMSF LTADNKSKMA KAGDVQSGGS DQERTKKKRR
     GDRYSVQTSL IVATLKKMLP IGLNMCAPTD QDLITLAKTR YALKDTDEEV REFLQNNLHL
     QGKVEGSPSL RWQMALYRGV PGREEDADDP EKIVRRVQEV SAVLYHLDQT EHPYKSKKAV
     WHKLLSKQRR RAVVACFRMT PLYNLPTHRA CNMLLESYKA TWILTEDHSF EDRMIDDLSK
     AGEQEEEEEE VEEKKPDPLH QLVLHFSRTA LTEKSKLDED YLYMAYADIM AKSCHLEEGG
     ENAEEGEEEE AEVSFEEKEM EKQRLLYQQA RLHNRGAAEM VLQMISACKG ETGAMVSSTL
     KLGISILNGG NAEVQQKMLD YLKDKKEVGF FQSIQALMQT CSVLDLNAFE RQNKAEGLGM
     VNEDGTVINR QNGEKVMADD EFTQDLFRFL QLLCEGHNND FQNYLRTQTG NTTTINIIIC
     TVDYLLRLQE SISDFYWYYS GKDVIEEQGK RNFSKAMSVA KQVFNSLTEY IQGPCTGNQQ
     SLAHSRLWDA VVGFLHVFAH MMMKLAQDSS QIELLKELLD LQKDMVVMLL SLLEGNVVNG
     MIARQMVDML VESSSNVEMI LKFFDMFLKL KDIVGSEAFQ DYVTDPRGLI SKKDFQKAMD
     SQKQFTGPEI QFLLSCSEAD ENEMINCEEF ANRFQEPARD IGFNVAVLLT NLSEHVPHDP
     RLRNFLELAE SILEYFRPYL GRIEIMGSSR RIERIYFEIS ETNRAQWEMP QVKESKRQFI
     FDVVNEGGES EKMELFVSFC EDTIFEMQIA AQISEPEGEP ETEEDEGASA GEAGTEGAEE
     GAEGPEGAAS ATAAAPGVTA RAAAAAGRAL SGLSYRSLRR RIRRLRRLTA REAATAAAAL
     LWAAVTRVGA AGVGAAAGAL RLLWGSLFGG GLVEGAKKVT VTELLAGMPD PTGDEVHGEQ
     PAGPGGETDG EGAGEGAGDT TEGADQEEAV AHEAGPGGAD GVVAVSEGGP FRPEGAGGLG
     DMGDTTPAEP PTPEGSPILK RKLGVDGEEE LLPEPEPQPE PEPEPEKADA ENGEKEEVPE
     PPPEPPKKKA PPPAPPKKEE AWSEFWGELE VQRVKFLNYL SRNFYTLRFL ALFLAFAINF
     ILLFYKVSDS PPGEDDMEGS ATGDLSGAGA GGGSGWGSGA GEEAEGEEDE NMVYYFLEES
     TGYMEPALRC LSLLHTLVAF LCIIGYNCLK VPLVIFKREK ELARKLEFDG LYITEQPEDD
     DVKGQWDRLV LNTPSFPSNY WDKFVKRKVL DKHGDIYGRE RIAELLGMDL ASLEITAHNE
     RKPSPPPGLL TWLMSIDVKY QIWKFGVIFT DNSFLYLTWY MVMSLLGHYN NFFFAAHLLD
     IAMGVKTLRT ILSSVTHNGK QLVMTVGLLA VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK
     CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA GDEYELYRVV FDITFFFFVI VILLAIIQGL
     IIDAFGELRD QQEQVKEDME TKCFICGIGS DYFDTTPHGF ETHTLEEHNL ANYMFFLMYL
     INKDETEHTG QESYVWKMYQ ERCWDFFPAG DCFRKQYEDQ LS
//
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