ID H0Y1H3_OTOGA Unreviewed; 134 AA.
AC H0Y1H3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 14 {ECO:0000256|RuleBase:RU369059};
GN Name=PPP1R14B {ECO:0000313|Ensembl:ENSOGAP00000022216.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000022216.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000022216.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Inhibitor of PPP1CA. {ECO:0000256|RuleBase:RU369059}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369059}.
CC -!- SIMILARITY: Belongs to the PP1 inhibitor family.
CC {ECO:0000256|ARBA:ARBA00005483, ECO:0000256|RuleBase:RU369059}.
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DR EMBL; AAQR03147538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03147539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03147540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0Y1H3; -.
DR STRING; 30611.ENSOGAP00000022216; -.
DR Ensembl; ENSOGAT00000032663.1; ENSOGAP00000022216.1; ENSOGAG00000030926.1.
DR eggNOG; KOG0824; Eukaryota.
DR GeneTree; ENSGT00950000182985; -.
DR HOGENOM; CLU_114155_1_0_1; -.
DR InParanoid; H0Y1H3; -.
DR OMA; DMDSDEH; -.
DR TreeFam; TF105546; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0042325; P:regulation of phosphorylation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.220; CPI-17; 1.
DR InterPro; IPR008025; CPI-17.
DR InterPro; IPR036658; CPI-17_sf.
DR PANTHER; PTHR16188; PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C; 1.
DR PANTHER; PTHR16188:SF5; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14B; 1.
DR Pfam; PF05361; PP1_inhibitor; 1.
DR SUPFAM; SSF81790; Myosin phosphatase inhibitor 17kDa protein, CPI-17; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU369059};
KW Phosphoprotein {ECO:0000256|RuleBase:RU369059};
KW Protein phosphatase inhibitor {ECO:0000256|ARBA:ARBA00023272,
KW ECO:0000256|RuleBase:RU369059};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 49..90
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 134 AA; 15081 MW; CD92A3C144C8384A CRC64;
PFKGVWSGGG GGPRVYFQSP PGAAGEGPGG TDDEGPVRRQ GKVTVKYDRK ELRKRLNLEE
WILEQLTRLY DCQEEEIPEL EIDVDELLDM ESDDTRAARV KELLVDCYKP TEAFISGLLD
KIRGMQKLST PQKK
//
