ID H0Y2G4_OTOGA Unreviewed; 359 AA.
AC H0Y2G4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=PBX homeobox 3 {ECO:0000313|Ensembl:ENSOGAP00000022557.1};
GN Name=PBX3 {ECO:0000313|Ensembl:ENSOGAP00000022557.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000022557.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000022557.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family.
CC {ECO:0000256|ARBA:ARBA00007601}.
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DR EMBL; AAQR03035665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03035674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012657914.1; XM_012802460.1.
DR AlphaFoldDB; H0Y2G4; -.
DR SMR; H0Y2G4; -.
DR STRING; 30611.ENSOGAP00000022557; -.
DR Ensembl; ENSOGAT00000034665.1; ENSOGAP00000022557.1; ENSOGAG00000031460.1.
DR GeneID; 100948268; -.
DR CTD; 5090; -.
DR eggNOG; KOG0774; Eukaryota.
DR GeneTree; ENSGT00940000154374; -.
DR HOGENOM; CLU_041153_0_0_1; -.
DR InParanoid; H0Y2G4; -.
DR OMA; SITVSQX; -.
DR OrthoDB; 3684468at2759; -.
DR TreeFam; TF314340; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0021516; P:dorsal spinal cord development; IEA:Ensembl.
DR GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR GO; GO:0002087; P:regulation of respiratory gaseous exchange by nervous system process; IEA:Ensembl.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005542; PBX_PBC_dom.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR PANTHER; PTHR11850:SF97; PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 3; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 1..159
FT /note="PBC"
FT /evidence="ECO:0000259|PROSITE:PS51978"
FT DOMAIN 158..221
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 160..222
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 251..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 39175 MW; 0DDC2CEC05DCE51A CRC64;
MKPALFSVLC EIKEKTGLSI RGAQEEDPPD PQLMRLDNML LAEGVSGPEK GGGSAAAAAA
AAASGGSSDN SIEHSDYRAK LTQIRQIYHT ELEKYEQACN EFTTHVMNLL REQSRTRPIS
PKEIERMVGI IHRKFSSIQM QLKQSTCEAV MILRSRFLDA RRKRRNFSKQ ATEILNEYFY
SHLSNPYPSE EAKEELAKKC SITVSQVSNW FGNKRIRYKK NIGKFQEEAN LYAAKTAVTA
AHAVAAAVQN NQTNSPTTPN SGSSGSFNLP NSGDMFMNMQ SLNGDSYQGS QVGANVQSQV
DTLRHVINQT GGYSDGLGGN SLYSPHNLNA NGGWQDATTP SSVTSPTEGP GSVHSDTSN
//
