GenomeNet

Database: UniProt
Entry: H0Y382_HUMAN
LinkDB: H0Y382_HUMAN
Original site: H0Y382_HUMAN 
ID   H0Y382_HUMAN            Unreviewed;      1182 AA.
AC   H0Y382;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 3.
DT   25-OCT-2017, entry version 47.
DE   SubName: Full=Calcium-activated potassium channel subunit alpha-1 {ECO:0000313|Ensembl:ENSP00000361498};
DE   Flags: Fragment;
GN   Name=KCNMA1 {ECO:0000313|Ensembl:ENSP00000361498};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000361498, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000361498}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [3] {ECO:0000313|Ensembl:ENSP00000361498}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000361498}.
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DR   EMBL; AC011439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC021032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC067745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL157833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL607069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL627447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL731556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL731560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL731575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y382; -.
DR   PaxDb; H0Y382; -.
DR   PeptideAtlas; H0Y382; -.
DR   PRIDE; H0Y382; -.
DR   Ensembl; ENST00000372421; ENSP00000361498; ENSG00000156113.
DR   UCSC; uc057uie.1; human.
DR   EuPathDB; HostDB:ENSG00000156113.20; -.
DR   HGNC; HGNC:6284; KCNMA1.
DR   OpenTargets; ENSG00000156113; -.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   GeneTree; ENSGT00530000063026; -.
DR   ChiTaRS; KCNMA1; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000156113; -.
DR   ExpressionAtlas; H0Y382; baseline and differential.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF28; PTHR10027:SF28; 2.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Proteomics identification {ECO:0000213|MaxQB:H0Y382,
KW   ECO:0000213|PeptideAtlas:H0Y382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000361498}.
SQ   SEQUENCE   1182 AA;  132332 MW;  CACA9CD07315CDED CRC64;
     XNIHANHLSL DASSSSSSSS SSSSSSSSSS SSSSVHEPKM DALIIPVTME VPCDSRGQRM
     WWAFLASSMV TFFGGLFIIL LWRTLKYLWT VCCHCGGKTK EAQKINNGSS QADGTLKPVD
     EKEEAVAAEV GWMTSVKDWA GVMISAQTLT GRVLVVLVFA LSIGALVIYF IDSSNPIESC
     QNFYKDFTLQ IDMAFNVFFL LYFGLRFIAA NDKLWFWLEV NSVVDFFTVP PVFVSVYLNR
     SWLGLRFLRA LRLIQFSEIL QFLNILKTSN SIKLVNLLSI FISTWLTAAG FIHLVENSGD
     PWENFQNNQA LTYWECVYLL MVTMSTVGYG DVYAKTTLGR LFMVFFILGG LAMFASYVPE
     IIELIGNRKK YGGSYSAVSG RKHIVVCGHI TLESVSNFLK DFLHKDRDDV NVEIVFLHNI
     SPNLELEALF KRHFTQVEFY QGSVLNPHDL ARVKIESADA CLILANKYCA DPDAEDASNI
     MRVISIKNYH PKIRIITQML QYHNKAHLLN IPSWNWKEGD DAICLAELKL GFIAQSCLAQ
     GLSTMLANLF SMRSFIKIEE DTWQKYYLEG VSNEMYTEYL SSAFVGLSFP TVCELCFVKL
     KLLMIAIEYK SANRESRSRK RILINPGNHL KIQEGTLGFF IASDAKEVKR AFFYCKACHD
     DITDPKRIKK CGCKRLEDEQ PSTLSPKKKQ RNGGMRNSPN TSPKLMRHDP LLIPGNDQID
     NMDSNVKKYD STGMFHWCAP KEIEKVILTR SEAAMTVLSG HVVVCIFGDV SSALIGLRNL
     VMPLRASNFH YHELKHIVFV GSIEYLKREW ETLHNFPKVS ILPGTPLSRA DLRAVNINLC
     DMCVILSANQ NNIDDTSLQD KECILASLNI KSMQFDDSIG VLQANSQGFT PPGMDRSSPD
     NSPVHGMLRQ PSITTGVNIP IITELAKPGK LPLVSVNQEK NSGTHILMIT ELVNDTNVQF
     LDQDDDDDPD TELYLTQPFA CGTAFAVSVL DSLMSATYFN DNILTLIRTL VTGGATPELE
     ALIAEENALR GGYSTPQTLA NRDRCRVAQL ALLDGPFADL GDGGCYGDLF CKALKTYNML
     CFGIYRLRDA HLSTPSQCTK RYVITNPPYE FELVPTDLIF CLMQFDHNAG QSRASLSHSS
     HSSQSSSKKS SSVHSIPSTA NRQNRPKSRE SRDKQKKEMV YR
//
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