ID H0Y6P9_HUMAN Unreviewed; 136 AA.
AC H0Y6P9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Phosphodiesterase 11A {ECO:0000313|Ensembl:ENSP00000406922.1};
DE Flags: Fragment;
GN Name=PDE11A {ECO:0000313|Ensembl:ENSP00000406922.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000406922.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000406922.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000406922.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC011998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC083824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF510770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0Y6P9; -.
DR PeptideAtlas; H0Y6P9; -.
DR Antibodypedia; 19565; 336 antibodies from 31 providers.
DR Ensembl; ENST00000436700.5; ENSP00000406922.1; ENSG00000128655.19.
DR UCSC; uc061qav.1; human.
DR HGNC; HGNC:8773; PDE11A.
DR VEuPathDB; HostDB:ENSG00000128655; -.
DR GeneTree; ENSGT00940000162151; -.
DR HOGENOM; CLU_1890490_0_0_1; -.
DR ChiTaRS; PDE11A; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000128655; Expressed in deltoid and 118 other cell types or tissues.
DR ExpressionAtlas; H0Y6P9; baseline and differential.
DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR InterPro; IPR023088; PDEase.
DR InterPro; IPR002073; PDEase_catalytic_dom.
DR InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR11347:SF130; DUAL 3',5'-CYCLIC-AMP AND -GMP PHOSPHODIESTERASE 11A; 1.
DR Pfam; PF00233; PDEase_I; 1.
DR PRINTS; PR00387; PDIESTERASE1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51845; PDEASE_I_2; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR623088-3};
KW Proteomics identification {ECO:0007829|PeptideAtlas:H0Y6P9,
KW ECO:0007829|ProteomicsDB:H0Y6P9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..115
FT /note="PDEase"
FT /evidence="ECO:0000259|PROSITE:PS51845"
FT BINDING 19
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000406922.1"
SQ SEQUENCE 136 AA; 15566 MW; F5C1BD6BDA091FE4 CRC64;
XVLPLVEERK ISMLMTACDL GAVTKPWEIS RQVAELVTSE FFEQGDRERL ELKLTPSAIF
DRNRKDELPR LQLEWIDSIC MPLYQALVKV NVKLKPMLDS VATNRSKWEE LHQKRLLAST
ASSSPASVMV AKEDRN
//
