ID H0YBE4_HUMAN Unreviewed; 79 AA.
AC H0YBE4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=glutathione peroxidase {ECO:0000256|ARBA:ARBA00012310};
DE EC=1.11.1.9 {ECO:0000256|ARBA:ARBA00012310};
DE Flags: Fragment;
GN Name=GPX3 {ECO:0000313|Ensembl:ENSP00000429314.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429314.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000429314.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000429314.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC {ECO:0000256|ARBA:ARBA00006926}.
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DR EMBL; AC008641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0YBE4; -.
DR PeptideAtlas; H0YBE4; -.
DR ProteomicsDB; 36694; -.
DR Antibodypedia; 8091; 288 antibodies from 32 providers.
DR Ensembl; ENST00000520059.1; ENSP00000429314.1; ENSG00000211445.13.
DR UCSC; uc063itp.1; human.
DR HGNC; HGNC:4555; GPX3.
DR VEuPathDB; HostDB:ENSG00000211445; -.
DR GeneTree; ENSGT00940000161754; -.
DR HOGENOM; CLU_2628260_0_0_1; -.
DR ChiTaRS; GPX3; human.
DR Proteomes; UP000005640; Chromosome 5.
DR Bgee; ENSG00000211445; Expressed in adult organism and 201 other cell types or tissues.
DR ExpressionAtlas; H0YBE4; baseline and differential.
DR GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000889; Glutathione_peroxidase.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11592; GLUTATHIONE PEROXIDASE; 1.
DR PANTHER; PTHR11592:SF32; GLUTATHIONE PEROXIDASE 3; 1.
DR Pfam; PF00255; GSHPx; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559};
KW Proteomics identification {ECO:0007829|EPD:H0YBE4,
KW ECO:0007829|MaxQB:H0YBE4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000429314.1"
SQ SEQUENCE 79 AA; 8844 MW; 78983ECD8D6F2375 CRC64;
XFGKQEPGEN SEILPTLKYV RPGGGFVPNF QLFEKGDVNG EKEQKFYTFL KGQAIPQEGL
GRKRVRGPQA RLTLLLSLL
//
