ID H0YDG7_HUMAN Unreviewed; 224 AA.
AC H0YDG7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Protein phosphatase 2 scaffold subunit Abeta {ECO:0000313|Ensembl:ENSP00000433598.1};
DE Flags: Fragment;
GN Name=PPP2R1B {ECO:0000313|Ensembl:ENSP00000433598.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433598.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000433598.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [4] {ECO:0000313|Ensembl:ENSP00000433598.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP000925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF455506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SwissPalm; H0YDG7; -.
DR MassIVE; H0YDG7; -.
DR MaxQB; H0YDG7; -.
DR PeptideAtlas; H0YDG7; -.
DR ProteomicsDB; 37390; -.
DR Antibodypedia; 3416; 394 antibodies from 36 providers.
DR Ensembl; ENST00000531890.1; ENSP00000433598.1; ENSG00000137713.16.
DR UCSC; uc058hey.1; human.
DR HGNC; HGNC:9303; PPP2R1B.
DR VEuPathDB; HostDB:ENSG00000137713; -.
DR GeneTree; ENSGT00950000183066; -.
DR HOGENOM; CLU_1242604_0_0_1; -.
DR ChiTaRS; PPP2R1B; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000137713; Expressed in sperm and 197 other cell types or tissues.
DR ExpressionAtlas; H0YDG7; baseline and differential.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10648:SF9; SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM; 1.
DR Pfam; PF02985; HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 5.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H0YDG7,
KW ECO:0007829|MaxQB:H0YDG7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 39..77
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 78..116
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 117..152
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 162..200
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 201..224
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000433598.1"
FT NON_TER 224
FT /evidence="ECO:0000313|Ensembl:ENSP00000433598.1"
SQ SEQUENCE 224 AA; 24755 MW; 084136DCAE3E2E17 CRC64;
XNLLKDCEAE VRAAAAHKVK ELGENLPIED RETIIMNQIL PYIKELVSDT NQHVKSALAS
VIMGLSTILG KENTIEHLLP LFLAQLKDEC PDVRLNIISN LDCVNEVIGI RQLSQSLLPA
IVELAEDAKW RVRLAIIEYM PLLAGQLALS EACGQEITTK QMLPIVLKMA GDQVANVRFN
VAKSLQKIGP ILDTNALQGE VKPVLQKLGQ DEDMDVKYFA QEAI
//
